Flavonoids from the bark of Artocarpus integer var. silvestris and their anti-inflammatory properties

Masuri Kama Kamaruddin Shah, Hasnah Mohd Sirat, Shajarahtunnur Jamil, Juriyati Jalil

Research output: Contribution to journalArticle

Abstract

A new pyranoflavone, methoxycyclocommunol (1) together with four known flavonoids, artonin F (2), heteroflavanone A (3), cudraflavone C (4) and cyclocommunol (5) were isolated from the bark of Artocarpus integer var. silvestris Corner. Their structures were elucidated through extensive spectroscopic techniques (UV, IR, MS, 1D-NMR and 2D-NMR) and by comparison with literature data. All the pure compounds were tested for their anti-inflammatory activities by using screening kit and radioimmunoassay methods. In a 15-lipoxygenase (15-LOX) inhibitory assay, compounds 1, 2, 4 and 5 gave weak percentages of inhibition, 16.5, 18.3, 17.6, 10.2%, respectively at the concentration of 100 μM. Compounds 1, 3 and 4, however, showed strong dose-dependent inhibition towards prostaglandin E2 (PGE2) production in lipopolysaccharide-induced human whole blood using a radioimmunoassay method with IC50 values of 4.3, 0.8, and 0.07 μM, respectively suggesting that they strongly exhibited cyclooxygenase-2 (COX-2) activity.

Original languageEnglish
Pages (from-to)1275-1278
Number of pages4
JournalNatural Product Communications
Volume11
Issue number9
Publication statusPublished - 2016

Fingerprint

Artocarpus integer
Artocarpus
anti-inflammatory activity
Flavonoids
Radioimmunoassay
bark
Anti-Inflammatory Agents
flavonoids
Arachidonate 15-Lipoxygenase
radioimmunoassays
Cyclooxygenase 2
Dinoprostone
Inhibitory Concentration 50
Lipopolysaccharides
prostaglandin synthase
lipoxygenase
lipopolysaccharides
prostaglandins
inhibitory concentration 50
methodology

Keywords

  • 15-lipoxygenase (15-LOX)
  • Artocarpus integer var. silvestris
  • Cyclooxygenase-2 (COX-2)
  • Methoxycyclocommunol
  • Prostaglandin E (PGE)

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Flavonoids from the bark of Artocarpus integer var. silvestris and their anti-inflammatory properties. / Shah, Masuri Kama Kamaruddin; Sirat, Hasnah Mohd; Jamil, Shajarahtunnur; Jalil, Juriyati.

In: Natural Product Communications, Vol. 11, No. 9, 2016, p. 1275-1278.

Research output: Contribution to journalArticle

Shah, Masuri Kama Kamaruddin ; Sirat, Hasnah Mohd ; Jamil, Shajarahtunnur ; Jalil, Juriyati. / Flavonoids from the bark of Artocarpus integer var. silvestris and their anti-inflammatory properties. In: Natural Product Communications. 2016 ; Vol. 11, No. 9. pp. 1275-1278.
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