Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases

Manish Putteeraj, Wei Ling Lim, Seong Lin Teoh, Mohamad Fairuz Yahaya

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Brain ischemia is among the leading cause of death with majority of the cases are associated with ischemic strokes. It can occur in two forms of either focal or global ischemia. Neurodegenerative disorder such as Alzheimer and Parkinson diseases is also on the rise worldwide. These disorders have common similarities; i.e. they all affecting the central nervous system with debilitating effect to the patient. In this review, we look into the promising role of flavonoids, a natural bioactive compound found abundant in vegetables, fruits and traditional herbs. Treatment with flavonoids such as curcumin, lycopene, ginsenoside, vitexin and baicalin have shown promising neuroprotective effects against ischemic-induced injury. Besides anticancer, antioxidant and immunomodulation properties, flavonoid also exerts neuroprotective effects by increases neuronal viability, increases tissue perfusion and cerebral blood flow and reduce ischemic-related apoptosis. In addition, flavonoid also exerts anti-amyloidogenic effect and reduces loss of dopaminergic neurons in the brain. These results suggesting flavonoids might be able to serve as a potential therapeutic agent in brain disorders.

Original languageEnglish
Pages (from-to)1710-1720
Number of pages11
JournalCurrent Drug Targets
Volume19
Issue number14
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Neurodegenerative diseases
Brain Diseases
Neuroprotective Agents
Brain Ischemia
Flavonoids
Neurodegenerative Diseases
Brain
Cerebrovascular Circulation
Ginsenosides
Tissue Survival
Curcumin
Immunomodulation
Dopaminergic Neurons
Vegetables
Neurology
Fruits
Neurons
Parkinson Disease
Cause of Death
Fruit

Keywords

  • Alzheimer disease
  • herb
  • Ischemia
  • natural products
  • Parkinson disease
  • polyphenol.

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases. / Putteeraj, Manish; Lim, Wei Ling; Teoh, Seong Lin; Yahaya, Mohamad Fairuz.

In: Current Drug Targets, Vol. 19, No. 14, 01.01.2018, p. 1710-1720.

Research output: Contribution to journalArticle

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