Fish oil-based oleogels

Physicochemicals characterisation and in vitro release of betamethasone dipropionate

Mohammad Fahmi Daman Huri, Shiow Fern Ng, Mohd Hanif Zulfakar

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: The aim of this work was to develop and characterise a novel oleogel formulation using fish oil as the lipid phase for the topical delivery of BD. Methods: Fish oil oleogels containing 0.05 % w/w BD were prepared using two types of oleogelators, namely Beeswax and Span 60. The organoleptic properties, microscopic structures,textural analysis, rheological properties, drug uniformity, storage stability and in vitro drug release profile of each oleogel formulations was investigated.A commercial preparation, Beprosone ointment was used as a control. Results: Oleogel formulated withmore than 10% w/w beeswax (FHB, FHC, FHD)displayed the most desirable properties compared to other oleogels. They showed pseudoplastic flow, smooth texture, physically stable during storage for up to six months and showed significantly higher BD flux compared tocontrol. Conclusion: A novel oleogel formulation based on fish oil was successfully developed and the enhancement of BD release highlighted the potential of fish oil that can be exploited as a novel vehicle for topical formulations.

Original languageEnglish
Pages (from-to)458-467
Number of pages10
JournalInternational Journal of Pharmacy and Pharmaceutical Sciences
Volume5
Issue number3
Publication statusPublished - 2013

Fingerprint

Fish Oils
Drug Storage
Ointments
oleogels
In Vitro Techniques
betamethasone-17,21-dipropionate
Lipids

Keywords

  • Beeswax
  • Betamethasone dipropionate
  • Fish oil
  • Oleogel
  • Span 60

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

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title = "Fish oil-based oleogels: Physicochemicals characterisation and in vitro release of betamethasone dipropionate",
abstract = "Objective: The aim of this work was to develop and characterise a novel oleogel formulation using fish oil as the lipid phase for the topical delivery of BD. Methods: Fish oil oleogels containing 0.05 {\%} w/w BD were prepared using two types of oleogelators, namely Beeswax and Span 60. The organoleptic properties, microscopic structures,textural analysis, rheological properties, drug uniformity, storage stability and in vitro drug release profile of each oleogel formulations was investigated.A commercial preparation, Beprosone ointment was used as a control. Results: Oleogel formulated withmore than 10{\%} w/w beeswax (FHB, FHC, FHD)displayed the most desirable properties compared to other oleogels. They showed pseudoplastic flow, smooth texture, physically stable during storage for up to six months and showed significantly higher BD flux compared tocontrol. Conclusion: A novel oleogel formulation based on fish oil was successfully developed and the enhancement of BD release highlighted the potential of fish oil that can be exploited as a novel vehicle for topical formulations.",
keywords = "Beeswax, Betamethasone dipropionate, Fish oil, Oleogel, Span 60",
author = "{Daman Huri}, {Mohammad Fahmi} and Ng, {Shiow Fern} and Zulfakar, {Mohd Hanif}",
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pages = "458--467",
journal = "International Journal of Pharmacy and Pharmaceutical Sciences",
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T2 - Physicochemicals characterisation and in vitro release of betamethasone dipropionate

AU - Daman Huri, Mohammad Fahmi

AU - Ng, Shiow Fern

AU - Zulfakar, Mohd Hanif

PY - 2013

Y1 - 2013

N2 - Objective: The aim of this work was to develop and characterise a novel oleogel formulation using fish oil as the lipid phase for the topical delivery of BD. Methods: Fish oil oleogels containing 0.05 % w/w BD were prepared using two types of oleogelators, namely Beeswax and Span 60. The organoleptic properties, microscopic structures,textural analysis, rheological properties, drug uniformity, storage stability and in vitro drug release profile of each oleogel formulations was investigated.A commercial preparation, Beprosone ointment was used as a control. Results: Oleogel formulated withmore than 10% w/w beeswax (FHB, FHC, FHD)displayed the most desirable properties compared to other oleogels. They showed pseudoplastic flow, smooth texture, physically stable during storage for up to six months and showed significantly higher BD flux compared tocontrol. Conclusion: A novel oleogel formulation based on fish oil was successfully developed and the enhancement of BD release highlighted the potential of fish oil that can be exploited as a novel vehicle for topical formulations.

AB - Objective: The aim of this work was to develop and characterise a novel oleogel formulation using fish oil as the lipid phase for the topical delivery of BD. Methods: Fish oil oleogels containing 0.05 % w/w BD were prepared using two types of oleogelators, namely Beeswax and Span 60. The organoleptic properties, microscopic structures,textural analysis, rheological properties, drug uniformity, storage stability and in vitro drug release profile of each oleogel formulations was investigated.A commercial preparation, Beprosone ointment was used as a control. Results: Oleogel formulated withmore than 10% w/w beeswax (FHB, FHC, FHD)displayed the most desirable properties compared to other oleogels. They showed pseudoplastic flow, smooth texture, physically stable during storage for up to six months and showed significantly higher BD flux compared tocontrol. Conclusion: A novel oleogel formulation based on fish oil was successfully developed and the enhancement of BD release highlighted the potential of fish oil that can be exploited as a novel vehicle for topical formulations.

KW - Beeswax

KW - Betamethasone dipropionate

KW - Fish oil

KW - Oleogel

KW - Span 60

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