Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation

E. Zahedi, R. Jaafar, M. A. Mohd Ali, A. L. Mohamed, Oteh Maskon

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

This study was conducted to investigate the utility and efficacy of finger photoplethysmogram pulse amplitude (PPG-AC) in comparison with the standard Doppler ultrasound in assessing an endothelial function via flow-mediated dilation (FMD). High-resolution B-mode scanning of the right brachial artery (BA) of 31 healthy subjects aged 39.7 ± 11.3 (range 22-64) years and 52 risk subjects aged 47.7 ± 10.8 (range 30-65) years were performed before and after 4 min of upper arm occlusion. Concurrent with the ultrasound measurement (where color Doppler imaging was used to enhance arterial boundary detection), PPG signals were recorded from both index fingers for cross evaluation and comparison. Our results show that the finger PPG-AC exhibits a similar response to that of the well-known BA dilation: following the release of pressure (cuff around the BA), the PPG-AC increases abruptly before slowly decreasing toward the baseline. The peak PPG-AC is reached significantly faster than the peak FMD measured by ultrasound among healthy and risk groups (P < 0.001). The proposed technique using a finger photoplethysmogram can be applied in a rapid and non-invasive assessment of peripheral vascular functions as an alternative low-cost and less operator-dependent tool compared to ultrasound.

Original languageEnglish
Pages (from-to)625-637
Number of pages13
JournalPhysiological Measurement
Volume29
Issue number5
DOIs
Publication statusPublished - 1 May 2008

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Fingers
Brachial Artery
Pulse
Dilatation
Ultrasonics
Doppler Ultrasonography
Signal detection
Blood Vessels
Mathematical operators
Healthy Volunteers
Arm
Color
Scanning
Imaging techniques
Pressure
Costs and Cost Analysis
Costs

Keywords

  • Endothelial function
  • Flow-mediated dilation
  • Photoplethysmography
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics

Cite this

Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation. / Zahedi, E.; Jaafar, R.; Mohd Ali, M. A.; Mohamed, A. L.; Maskon, Oteh.

In: Physiological Measurement, Vol. 29, No. 5, 01.05.2008, p. 625-637.

Research output: Contribution to journalArticle

Zahedi, E, Jaafar, R, Mohd Ali, MA, Mohamed, AL & Maskon, O 2008, 'Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation', Physiological Measurement, vol. 29, no. 5, pp. 625-637. https://doi.org/10.1088/0967-3334/29/5/008
Zahedi, E. ; Jaafar, R. ; Mohd Ali, M. A. ; Mohamed, A. L. ; Maskon, Oteh. / Finger photoplethysmogram pulse amplitude changes induced by flow-mediated dilation. In: Physiological Measurement. 2008 ; Vol. 29, No. 5. pp. 625-637.
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