Fat intake and its relationship with pre- and postmenopausal breast cancer risk

A case-control study in Malaysia

Suhaina Sulaiman, Mohd Razif Shahril, Soraya Hanie Shaharudin, Nor Aina Emran, Rohaizak Muhammad, Fuad Ismail, Sharifah Noor Akmal Syed Husain

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. Objective: To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. Methodology: This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis. Results: This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36). Conclusion: Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.

Original languageEnglish
Pages (from-to)2167-2178
Number of pages12
JournalAsian Pacific Journal of Cancer Prevention
Volume12
Issue number9
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

Malaysia
Case-Control Studies
Fats
Confidence Intervals
Breast Neoplasms
Odds Ratio
Energy Intake

Keywords

  • Breast cancer
  • Mono-unsaturated
  • Polyunsaturated
  • Postmenopausal
  • Premenopausal
  • Total fat

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Public Health, Environmental and Occupational Health
  • Epidemiology

Cite this

Fat intake and its relationship with pre- and postmenopausal breast cancer risk : A case-control study in Malaysia. / Sulaiman, Suhaina; Shahril, Mohd Razif; Shaharudin, Soraya Hanie; Emran, Nor Aina; Muhammad, Rohaizak; Ismail, Fuad; Husain, Sharifah Noor Akmal Syed.

In: Asian Pacific Journal of Cancer Prevention, Vol. 12, No. 9, 2011, p. 2167-2178.

Research output: Contribution to journalArticle

Sulaiman, Suhaina ; Shahril, Mohd Razif ; Shaharudin, Soraya Hanie ; Emran, Nor Aina ; Muhammad, Rohaizak ; Ismail, Fuad ; Husain, Sharifah Noor Akmal Syed. / Fat intake and its relationship with pre- and postmenopausal breast cancer risk : A case-control study in Malaysia. In: Asian Pacific Journal of Cancer Prevention. 2011 ; Vol. 12, No. 9. pp. 2167-2178.
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abstract = "Background: Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. Objective: To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. Methodology: This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95{\%} confidence intervals (CI) and a broad range of potential confounders was included in analysis. Results: This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95{\%} CI, 0.23-2.45 and OR=1.36, 95{\%} CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95{\%} CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95{\%} CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95{\%} CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95{\%} CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95{\%} CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95{\%} CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95{\%} CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95{\%} CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95{\%} CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95{\%} CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95{\%} CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95{\%} CI, 0.93-3.36). Conclusion: Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.",
keywords = "Breast cancer, Mono-unsaturated, Polyunsaturated, Postmenopausal, Premenopausal, Total fat",
author = "Suhaina Sulaiman and Shahril, {Mohd Razif} and Shaharudin, {Soraya Hanie} and Emran, {Nor Aina} and Rohaizak Muhammad and Fuad Ismail and Husain, {Sharifah Noor Akmal Syed}",
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T1 - Fat intake and its relationship with pre- and postmenopausal breast cancer risk

T2 - A case-control study in Malaysia

AU - Sulaiman, Suhaina

AU - Shahril, Mohd Razif

AU - Shaharudin, Soraya Hanie

AU - Emran, Nor Aina

AU - Muhammad, Rohaizak

AU - Ismail, Fuad

AU - Husain, Sharifah Noor Akmal Syed

PY - 2011

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N2 - Background: Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. Objective: To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. Methodology: This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis. Results: This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36). Conclusion: Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.

AB - Background: Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. Objective: To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. Methodology: This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis. Results: This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36). Conclusion: Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.

KW - Breast cancer

KW - Mono-unsaturated

KW - Polyunsaturated

KW - Postmenopausal

KW - Premenopausal

KW - Total fat

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