Fabrication and characterization of matrix type transdermal patches loaded with tizanidine hydrochloride

potential sustained release delivery system

Nabeel Shahid, Muhammad Irfan Siddique, Zunera Razzaq, Haliza Katas, Muhammad Khurram Waqas, Kashif Ur Rahman

Research output: Contribution to journalArticle

Abstract

Objective: This study was designed to optimize and develop matrix type transdermal drug delivery system (TDDS) containing tizanidine hydrochloride (TZH) using different polymers by solvent evaporation method. Significance: A strong need exists for the development of transdermal patch having improved bioavailability at the site of action with fewer side effects at off-target organs. Methods: The patches were physically characterized by texture analysis (color, flexibility, smoothness, transparency, and homogeneity), in vitro dissolution test and FTIR analysis. Furthermore, functional properties essential for TDDS, in vitro percentage of moisture content, percentage of water uptake, in vitro permeation by following different kinetic models, in vivo drug content estimation and skin irritation were determined using rabbit skin. Results: The optimized patches were soft, of uniform texture and thickness as well as pliable in nature. Novel transdermal patch showed ideal characteristics in terms of moisture content and water uptake. FTIR analysis confirmed no interaction between TZH and cellulose acetate phthalate (CAP). The patch showed sustained release of the drug which increased the availability of short acting TZH at the site of action. The patch also showed its biocompatibility to the in vivo model of rabbit skin. Conclusions: The results demonstrated that topically applied transdermal patch will be a potential medicated sustain release patch for muscle pain which will improve patient compliance.

Original languageEnglish
Pages (from-to)2061-2070
Number of pages10
JournalDrug Development and Industrial Pharmacy
Volume44
Issue number12
DOIs
Publication statusPublished - 2 Dec 2018

Fingerprint

Transdermal Patch
Skin
Fourier Transform Infrared Spectroscopy
Drug Delivery Systems
Fabrication
Moisture
Textures
Essential Drugs
Rabbits
Water
Myalgia
Patient Compliance
Biocompatibility
Permeation
Pharmaceutical Preparations
Transparency
Biological Availability
Muscle
Polymers
Dissolution

Keywords

  • permeation enhancer
  • skin
  • tizanidine hydrochloride
  • Transdermal patches

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this

Fabrication and characterization of matrix type transdermal patches loaded with tizanidine hydrochloride : potential sustained release delivery system. / Shahid, Nabeel; Siddique, Muhammad Irfan; Razzaq, Zunera; Katas, Haliza; Waqas, Muhammad Khurram; Rahman, Kashif Ur.

In: Drug Development and Industrial Pharmacy, Vol. 44, No. 12, 02.12.2018, p. 2061-2070.

Research output: Contribution to journalArticle

Shahid, Nabeel ; Siddique, Muhammad Irfan ; Razzaq, Zunera ; Katas, Haliza ; Waqas, Muhammad Khurram ; Rahman, Kashif Ur. / Fabrication and characterization of matrix type transdermal patches loaded with tizanidine hydrochloride : potential sustained release delivery system. In: Drug Development and Industrial Pharmacy. 2018 ; Vol. 44, No. 12. pp. 2061-2070.
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