External-beam Radiotherapy in T1-2 N0 Penile Carcinoma

M. Azrif, J. P. Logue, R. Swindell, R. A. Cowan, J. P. Wylie, J. E. Livsey

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Aims: To review the outcome of 41 patients with invasive carcinoma of the penis treated with external-beam radiotherapy using a consistent technique and dose. Materials and methods: Forty-one patients with carcinoma of the penis treated at Christie Hospital, Manchester, UK, between 1995 and 2000 were reviewed retrospectively. Radiotherapy was delivered using 4 MV linear accelerators with a dose of 50 Gy or 52.5 Gy in 16 fractions over 22 days. Results: The distribution of patients according to stage was T1 = 37, T2 = 4, N0 = 40, N3 = 1. Median follow-up was 4.5 years. The local control rate was 62%, nodal relapse-free rate of 88%, relapse-free rate of 51% and overall survival of 88% at 5 years. All recurrences were salvaged by surgery. Penile ulceration occurred in 8% and urethral stenosis requiring dilatation in 29%. There were no penectomies for penile necrosis. Conclusion: EBXRT may be offered for T1-2 cancer of the penis with close surveillance to detect local recurrences early for salvage surgery without jeopardising overall survival. It remains an alternative option to penis-preserving surgery and should be discussed in a multidisciplinary setting and with the patient.

Original languageEnglish
Pages (from-to)320-325
Number of pages6
JournalClinical Oncology
Volume18
Issue number4
DOIs
Publication statusPublished - May 2006
Externally publishedYes

Fingerprint

Penis
Radiotherapy
Carcinoma
Recurrence
Penile Neoplasms
Urethral Stricture
Particle Accelerators
Survival
Dilatation
Necrosis

Keywords

  • Carcinoma
  • penis
  • radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

Cite this

Azrif, M., Logue, J. P., Swindell, R., Cowan, R. A., Wylie, J. P., & Livsey, J. E. (2006). External-beam Radiotherapy in T1-2 N0 Penile Carcinoma. Clinical Oncology, 18(4), 320-325. https://doi.org/10.1016/j.clon.2006.01.004

External-beam Radiotherapy in T1-2 N0 Penile Carcinoma. / Azrif, M.; Logue, J. P.; Swindell, R.; Cowan, R. A.; Wylie, J. P.; Livsey, J. E.

In: Clinical Oncology, Vol. 18, No. 4, 05.2006, p. 320-325.

Research output: Contribution to journalArticle

Azrif, M, Logue, JP, Swindell, R, Cowan, RA, Wylie, JP & Livsey, JE 2006, 'External-beam Radiotherapy in T1-2 N0 Penile Carcinoma', Clinical Oncology, vol. 18, no. 4, pp. 320-325. https://doi.org/10.1016/j.clon.2006.01.004
Azrif M, Logue JP, Swindell R, Cowan RA, Wylie JP, Livsey JE. External-beam Radiotherapy in T1-2 N0 Penile Carcinoma. Clinical Oncology. 2006 May;18(4):320-325. https://doi.org/10.1016/j.clon.2006.01.004
Azrif, M. ; Logue, J. P. ; Swindell, R. ; Cowan, R. A. ; Wylie, J. P. ; Livsey, J. E. / External-beam Radiotherapy in T1-2 N0 Penile Carcinoma. In: Clinical Oncology. 2006 ; Vol. 18, No. 4. pp. 320-325.
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