Extensive myelofibrosis responsive to treatment for acute erythroblastic leukaemia.

Research output: Contribution to journalArticle

Abstract

Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.

Original languageEnglish
Pages (from-to)55-58
Number of pages4
JournalThe Malaysian journal of pathology
Volume28
Issue number1
Publication statusPublished - Jun 2006

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Leukemia, Erythroblastic, Acute
Primary Myelofibrosis
Leukemia, Megakaryoblastic, Acute
Acute Myeloid Leukemia
Fibrosis
Bone Marrow
Myeloid Cells
Leukemia

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Extensive myelofibrosis responsive to treatment for acute erythroblastic leukaemia.",
abstract = "Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.",
author = "{S. Abdul Wahid}, {S Fadilah} and {Raja Sabudin}, {Raja Zahratul Azma} and {Chooi Fun}, Leong",
year = "2006",
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T1 - Extensive myelofibrosis responsive to treatment for acute erythroblastic leukaemia.

AU - S. Abdul Wahid, S Fadilah

AU - Raja Sabudin, Raja Zahratul Azma

AU - Chooi Fun, Leong

PY - 2006/6

Y1 - 2006/6

N2 - Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.

AB - Intense myelofibrosis is rarely associated with de novo acute myeloid leukaemia (AML) except in acute megakaryoblastic leukaemia (AML-M7) where there is diffuse marrow fibrosis as a consequence of proliferation of neoplastic myeloid cells. AML associated with significant myelofibrosis developing both de novo or secondary to primary (idiopathic) myelofibrosis is characterised by a fulminant course and extremely poor prognosis, primarily due to treatment-resistant disease. The prognostic value of degree of marrow fibrosis in de novo AML has been poorly investigated. We describe a case of extensive myelofibrosis associated with acute erythroblastic leukaemia (AML-M6) that responded to induction therapy of the leukaemia.

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