Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells

Noraidah Masir, Margaret Jones, Michela Pozzobon, Teresa Marafioti, Olga Y. Volkova, Ludmila V. Mechetina, Martin Leo Hansmann, Yasodha Natkunam, Alexander V. Taranin, David Y. Mason

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

FCRL (also known as FREB and FcRX) is a recently described member of the family of Fc receptors for immunoglobulin G (IgG). In the present study we analysed its expression in normal and neoplastic lymphoid tissue using immunohistochemical techniques. FCRL was preferentially expressed in a proportion of germinal centre cells and, more weakly, in mantle zone B cells. In addition, strong labelling was observed in marginal zone B cells in the spleen, representing one of the few markers for this cell type. The majority of cases of small B-cell lymphoma, diffuse large B-cell lymphoma and lymphocyte predominance Hodgkin's disease were positive for FCRL. However, the number of positive cells varied widely, and in consequence we could not define a cut-off that distinguished subsets of diffuse large B-cell lymphoma. Our results also showed that FCRL tended to be negative in T-cell-rich B-cell lymphoma and in classical Hodgkin's disease. FCRL may therefore represent a novel marker for normal B cells (e.g. splenic marginal zone cells) and may also be useful as a potential marker of B-cell neoplasms.

Original languageEnglish
Pages (from-to)335-343
Number of pages9
JournalBritish Journal of Haematology
Volume127
Issue number3
DOIs
Publication statusPublished - Nov 2004
Externally publishedYes

Fingerprint

B-Lymphocytes
B-Cell Lymphoma
Hodgkin Disease
Immunoglobulin Fc Fragments
Germinal Center
Fc Receptors
Lymphoma, Large B-Cell, Diffuse
Lymphoid Tissue
B-Cell Chronic Lymphocytic Leukemia
Spleen
Cell Count
Immunoglobulin G
T-Lymphocytes
Neoplasms

Keywords

  • B cells
  • Fc receptors
  • FCRL
  • Immunohistochemistry
  • Lymphoid neoplasms

ASJC Scopus subject areas

  • Hematology

Cite this

Masir, N., Jones, M., Pozzobon, M., Marafioti, T., Volkova, O. Y., Mechetina, L. V., ... Mason, D. Y. (2004). Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells. British Journal of Haematology, 127(3), 335-343. https://doi.org/10.1111/j.1365-2141.2004.05193.x

Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells. / Masir, Noraidah; Jones, Margaret; Pozzobon, Michela; Marafioti, Teresa; Volkova, Olga Y.; Mechetina, Ludmila V.; Hansmann, Martin Leo; Natkunam, Yasodha; Taranin, Alexander V.; Mason, David Y.

In: British Journal of Haematology, Vol. 127, No. 3, 11.2004, p. 335-343.

Research output: Contribution to journalArticle

Masir, N, Jones, M, Pozzobon, M, Marafioti, T, Volkova, OY, Mechetina, LV, Hansmann, ML, Natkunam, Y, Taranin, AV & Mason, DY 2004, 'Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells', British Journal of Haematology, vol. 127, no. 3, pp. 335-343. https://doi.org/10.1111/j.1365-2141.2004.05193.x
Masir, Noraidah ; Jones, Margaret ; Pozzobon, Michela ; Marafioti, Teresa ; Volkova, Olga Y. ; Mechetina, Ludmila V. ; Hansmann, Martin Leo ; Natkunam, Yasodha ; Taranin, Alexander V. ; Mason, David Y. / Expression pattern of FCRL (FREB, FcRX) in normal and neoplastic human B cells. In: British Journal of Haematology. 2004 ; Vol. 127, No. 3. pp. 335-343.
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