Exploring the immunomodulatory and anticancer properties of zerumbone

Md Areeful Haque, Ibrahim Jantan, Laiba Arshad, Bukhari Syed Nasir Abbas

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Plant-derived immunomodulators and anti-cancer agents have attracted a lot of interest from natural product scientists for their efficacy and safety and their significant contribution towards understanding targeted drug action and drug delivery mechanisms. Zerumbone, the main constituent of Zingiber zerumbet rhizomes, has been investigated for its wide-spectrum role in treating multitargeted diseases. The rhizomes have been used as food flavoring agents in various cuisines and in herbal medicine. Many in vivo and in vitro studies have provided evidence of zerumbone as a potent immunomodulator as well as a potential anti-cancer agent. This review is an interesting compilation of all those significant outcomes from investigations carried out to date to explore the immunomodulatory and anticancer properties of zerumbone. The ultimate objective of this comprehensive review is to provide updated information and a critical assessment on zerumbone including its chemistry and immunomodulating and anticancer properties, which may be of paramount importance to provide a new path for ensuing research to discover new agents to treat cancers and immune-related diseases. In addition, updated information on the toxicology of zerumbone has also been summarized to provide its safety profile.

Original languageEnglish
Pages (from-to)3410-3431
Number of pages22
JournalFood and Function
Volume8
Issue number10
DOIs
Publication statusPublished - 1 Oct 2017

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immunomodulators
antineoplastic agents
rhizomes
Zingiber zerumbet
cuisine
drugs
herbal medicines
flavorings
toxicology
Rhizome
in vitro studies
Immunologic Factors
foods
chemistry
Flavoring Agents
neoplasms
Safety
Neoplasms
Herbal Medicine
Immune System Diseases

ASJC Scopus subject areas

  • Food Science

Cite this

Exploring the immunomodulatory and anticancer properties of zerumbone. / Haque, Md Areeful; Jantan, Ibrahim; Arshad, Laiba; Syed Nasir Abbas, Bukhari.

In: Food and Function, Vol. 8, No. 10, 01.10.2017, p. 3410-3431.

Research output: Contribution to journalArticle

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