Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals

A review of pharmacokinetic and pharmacodynamic implications and future prospects

Hnin Thu, Zahid Hussain, Isa Naina Mohamed, Ahmad Nazrun Shuid

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer properties. This review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of E. longifolia and its bioactive components. Analysis of pharmacokinetic profile revealed that E. longifolia exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 isoenzymes. E. longifolia has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts (i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and humans. Among various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical (isolated or extracted from root extracts) against various types of animals and human diseases. Based on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that E. longifolia can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments.

Original languageEnglish
Pages (from-to)89-97
Number of pages9
JournalAsian Pacific Journal of Tropical Medicine
Volume11
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018
Externally publishedYes

Fingerprint

Eurycoma
Phytochemicals
Pharmacokinetics
Complementary Therapies
Aphrodisiacs
Animal Diseases
Herbal Medicine
Anti-Anxiety Agents
Antimalarials
Traditional Medicine
Rheumatic Diseases
Complex Mixtures
Cytochrome P-450 Enzyme System
Biological Availability
Isoenzymes
Ulcer
Anti-Inflammatory Agents
Antioxidants
Pharmacology
Therapeutics

Keywords

  • Eurycoma longifolia Jack
  • Eurycomanone
  • Pharmacodynamic algorithm
  • Pharmacokinetic profile
  • Quassinoids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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abstract = "Eurycoma longifolia Jack (E. longifolia) is a well-recognized traditional herbal medicine that offers a wide dynamic range of biomedical applications including anti-osteoporotic, anticancer, anti-proliferative, anti-malarial, antimicrobial, antioxidant, aphrodisiac, anti-inflammatory, anxiolytic, anti-diabetic, anti-rheumatism and anti-ulcer properties. This review aims to overview the pharmacokinetic and a pharmacodynamic algorithm of E. longifolia and its bioactive components. Analysis of pharmacokinetic profile revealed that E. longifolia exhibit higher bioavailability, high volume of distribution, slow elimination rate, and does not show inhibitory effects on cytochrome P450 isoenzymes. E. longifolia has been used, alone or in combination with other pharmacological agents, in the form of crude extracts, standard extracts, or decoctions of different plant parts (i.e., herbs, shrubs, stem, leaves, and roots) for the treatment of various ailments in animals and humans. Among various bioactive constituents, eurycomanone has been found to be the most remarkable, super-stable, versatile, and most potent phytochemical (isolated or extracted from root extracts) against various types of animals and human diseases. Based on its well-established pharmacokinetic and pharmacodynamic profiles, we suggested that E. longifolia can be a well-accepted complementary and alternative medicine for the treatment of different types of human ailments.",
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