Experimental fracture protocols in assessments of potential agents for osteoporotic fracture healing using rodent models

Nurul Izzah Ibrahim, Sharlina Mohamad, Norazlina Mohamed, Ahmad Nazrun Shuid

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Osteoporosis may cause bone fracture even under slight trauma. Osteoporotic fracture has become a major public health problem but until today, the treatments available are not satisfactory. Many pre-clinical testings on animals were done to find new agents that can be sourced from natural products and synthetic drugs for osteoporotic fracture healing. Animal models are more appropriate for fracture healing study than human subject due to several reasons including the ethical issues involved. The bones of rodents are similar to human in term of their morphological change and response to therapy. Small rodents such as rats and mice are suitable animal models for fracture healing studies as they have a similar bone remodeling system to human. To date, there is no specific guideline to carry out fracture healing studies in animal models for the evaluation of new agents. This paper highlights the protocols of various fracture and fixation methods for experimental osteoporotic fracture healing using rodent models.

Original languageEnglish
Pages (from-to)1642-1650
Number of pages9
JournalCurrent Drug Targets
Volume14
Issue number14
DOIs
Publication statusPublished - 2013

Fingerprint

Osteoporotic Fractures
Fracture Healing
Rodentia
Animal Models
Animals
Bone
Fracture Fixation
Bone Remodeling
Bone Fractures
Biological Products
Ethics
Osteoporosis
Public Health
Guidelines
Public health
Bone and Bones
Medical problems
Wounds and Injuries
Rats
Therapeutics

Keywords

  • Bone fracture
  • Fracture fixation
  • Fracture healing
  • Fracture method
  • Osteoporosis
  • Rodents

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Clinical Biochemistry
  • Molecular Medicine

Cite this

Experimental fracture protocols in assessments of potential agents for osteoporotic fracture healing using rodent models. / Ibrahim, Nurul Izzah; Mohamad, Sharlina; Mohamed, Norazlina; Shuid, Ahmad Nazrun.

In: Current Drug Targets, Vol. 14, No. 14, 2013, p. 1642-1650.

Research output: Contribution to journalArticle

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