Evaluation of trace elements in Malay women with type 2 diabetes mellitus

Mohammed Nashiry, Ismarulyusda Ishak, Jamaludin Mohamed, Siti Balkis Budin, M. N. Mohd Fairulnizal, Sazlina Kamaralzaman, Hesham M. Al-Mekhlafi

Research output: Contribution to journalArticle

Abstract

Trace elements are essential for human health. This study determines the level of chromium (Cr), zinc (Zn), selenium (Se), copper (Cu), ferrum (Fe) and manganese (Mn) in the hair and nails of married Malay women with type 2 diabetes mellitus from Hulu Langat, Selangor, Malaysia. The trace elements were analysed using inductively coupled plasma mass spectrometry (ICP-MS) after an acid digestion treatment. The levels of all trace elements measured were higher in the hair samples than in nails except for Se. Mean levels of Zn and Se were significantly higher in the hair of non-working women (84.91 ± 10.32 μg/g and 0.42 ± 0.15 μg/g, respectively) compared to working women (64.98 ± 11.10 μg/g and 0.30 ± 0.18 μg/g). Copper levels in hair were significantly higher among women with good and satisfactory diabetes control (20.41 ± 4.20 μg/g) compared to the poor diabetes control group (15.67 ± 4.31 μg/g). However, a contradictory result was obtained from the nails of women with good and satisfactory diabetes control with a Cu level of 3.35 ± 0.46 μg/g and 4.69 ± 0.33 μg/g for the poor diabetes control group. In hair samples, significant positive correlations were obtained with Cr-Cu (r = 0.55), Zn-Mn (r = 0.46) and Se-Mn (r = 0.38). In nails, significant positive correlations were also obtained between Cr-Zn (r = 0.31), Zn-Fe (r = 0.30) and Fe-Mn (r = 0.47). In conclusion, age, educational status, number of children and duration of diabetes did not influence trace elements levels.

Original languageEnglish
Pages (from-to)337-345
Number of pages9
JournalSains Malaysiana
Volume48
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019

Fingerprint

Trace Elements
Hair
Type 2 Diabetes Mellitus
Zinc
Manganese
Selenium
Nails
Chromium
Copper
Working Women
Control Groups
Educational Status
Malaysia
Digestion
Mass Spectrometry
Acids
Health

Keywords

  • Diabetes mellitus
  • Female
  • HbA1c
  • ICP-MS
  • Trace elements

ASJC Scopus subject areas

  • General

Cite this

Evaluation of trace elements in Malay women with type 2 diabetes mellitus. / Nashiry, Mohammed; Ishak, Ismarulyusda; Mohamed, Jamaludin; Budin, Siti Balkis; Mohd Fairulnizal, M. N.; Kamaralzaman, Sazlina; Al-Mekhlafi, Hesham M.

In: Sains Malaysiana, Vol. 48, No. 2, 01.02.2019, p. 337-345.

Research output: Contribution to journalArticle

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abstract = "Trace elements are essential for human health. This study determines the level of chromium (Cr), zinc (Zn), selenium (Se), copper (Cu), ferrum (Fe) and manganese (Mn) in the hair and nails of married Malay women with type 2 diabetes mellitus from Hulu Langat, Selangor, Malaysia. The trace elements were analysed using inductively coupled plasma mass spectrometry (ICP-MS) after an acid digestion treatment. The levels of all trace elements measured were higher in the hair samples than in nails except for Se. Mean levels of Zn and Se were significantly higher in the hair of non-working women (84.91 ± 10.32 μg/g and 0.42 ± 0.15 μg/g, respectively) compared to working women (64.98 ± 11.10 μg/g and 0.30 ± 0.18 μg/g). Copper levels in hair were significantly higher among women with good and satisfactory diabetes control (20.41 ± 4.20 μg/g) compared to the poor diabetes control group (15.67 ± 4.31 μg/g). However, a contradictory result was obtained from the nails of women with good and satisfactory diabetes control with a Cu level of 3.35 ± 0.46 μg/g and 4.69 ± 0.33 μg/g for the poor diabetes control group. In hair samples, significant positive correlations were obtained with Cr-Cu (r = 0.55), Zn-Mn (r = 0.46) and Se-Mn (r = 0.38). In nails, significant positive correlations were also obtained between Cr-Zn (r = 0.31), Zn-Fe (r = 0.30) and Fe-Mn (r = 0.47). In conclusion, age, educational status, number of children and duration of diabetes did not influence trace elements levels.",
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AB - Trace elements are essential for human health. This study determines the level of chromium (Cr), zinc (Zn), selenium (Se), copper (Cu), ferrum (Fe) and manganese (Mn) in the hair and nails of married Malay women with type 2 diabetes mellitus from Hulu Langat, Selangor, Malaysia. The trace elements were analysed using inductively coupled plasma mass spectrometry (ICP-MS) after an acid digestion treatment. The levels of all trace elements measured were higher in the hair samples than in nails except for Se. Mean levels of Zn and Se were significantly higher in the hair of non-working women (84.91 ± 10.32 μg/g and 0.42 ± 0.15 μg/g, respectively) compared to working women (64.98 ± 11.10 μg/g and 0.30 ± 0.18 μg/g). Copper levels in hair were significantly higher among women with good and satisfactory diabetes control (20.41 ± 4.20 μg/g) compared to the poor diabetes control group (15.67 ± 4.31 μg/g). However, a contradictory result was obtained from the nails of women with good and satisfactory diabetes control with a Cu level of 3.35 ± 0.46 μg/g and 4.69 ± 0.33 μg/g for the poor diabetes control group. In hair samples, significant positive correlations were obtained with Cr-Cu (r = 0.55), Zn-Mn (r = 0.46) and Se-Mn (r = 0.38). In nails, significant positive correlations were also obtained between Cr-Zn (r = 0.31), Zn-Fe (r = 0.30) and Fe-Mn (r = 0.47). In conclusion, age, educational status, number of children and duration of diabetes did not influence trace elements levels.

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