Evaluation of topical tocopherol cream on cutaneous wound healing in streptozotocin-induced diabetic rats

Seong Lin Teoh, Azian Abd Latiff, Noor Aini Abd Hamid, Wan Zurinah Bt Wan Ngah, Musalmah Mazlan

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Diabetes is a common cause of delayed wound healing. The aim of the study was to determine the effect of topical administration of tocopherol cream on the wound healing process in diabetic rats. The study was conducted using 18 male Sprague Dawley rats which were divided into three groups: (I) diabetic rats receiving control cream (n=6), (II) diabetic rats receiving 0.06 tocopherol cream (n=6), and (III) diabetic rats receiving 0.29 tocopherol cream (n=6). Four cutaneous wounds were created at the dorsal region of the rats. Wound healing was assessed by total protein content, rate of wound closure estimation, and histological studies on the tenth day after wounding. Tocopherol treatment enhanced the wound healing process by increasing rate of wound closure and total protein content significantly (P<0.05) compared to the control group. Histological observation also showed better organized epithelium and more collagen fibers in the tocopherol treated groups. Application of tocopherol cream enhances wound healing process in diabetic condition which is known to cause delay in wound healing.

Original languageEnglish
Article number491027
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012

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Tocopherols
Streptozocin
Wound Healing
Skin
Wounds and Injuries
Topical Administration
Sprague Dawley Rats
Proteins
Collagen
Epithelium
Observation
Control Groups

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

Evaluation of topical tocopherol cream on cutaneous wound healing in streptozotocin-induced diabetic rats. / Teoh, Seong Lin; Abd Latiff, Azian; Abd Hamid, Noor Aini; Wan Ngah, Wan Zurinah Bt; Mazlan, Musalmah.

In: Evidence-based Complementary and Alternative Medicine, Vol. 2012, 491027, 2012.

Research output: Contribution to journalArticle

Teoh, Seong Lin ; Abd Latiff, Azian ; Abd Hamid, Noor Aini ; Wan Ngah, Wan Zurinah Bt ; Mazlan, Musalmah. / Evaluation of topical tocopherol cream on cutaneous wound healing in streptozotocin-induced diabetic rats. In: Evidence-based Complementary and Alternative Medicine. 2012 ; Vol. 2012.
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