Evaluation of thermal, morphological and mechanical properties of PMMA/NaCl/DMF electrospun nanofibers

an investigation through surface methodology approach

Majid Niaz Akhtar, Abu Bakar Sulong, Saniah Ab Karim, Che Husna Azhari, M. R. Raza

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Electrospinning is an efficient, flexible and versatile method of producing nanofibers. The aims of this study are to fabrication and characterize electrospun nanofibers and evaluation of the electrospinning parameters that influence on the nanofibers properties. In this work, polymethylmetacrylate (PMMA) and sodium chloride were dissolved in dimethylformamide for fabrication of PMMA nanofibers through electrospinning. Differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and mechanical testing were used to measure the structure, morphology, diameter, orientation and strength of the nanofibers, respectively. The effect of electrospinning parameters on diameter, morphology and mechanical properties of nanofibers was also investigated. Collector rotating speed and gap distance were also found to be the most important factors that affected diameter and orientation of the nanofibers. Response surface methodology L46 and Box–Behnken experimental design were used to analyze and optimize the results. The theoretical and experimental study revealed that increasing the gap between collector and needle resulted in reduction of the electrospun nanofibers. However, fiber diameter was significantly influenced by decreasing the solution concentration and pump rate. Moreover, fibers with ~720 nm diameter and ~90 % of orientation possessed an ultimate tensile strength of 1.4 MPa, which was exhibited at the following optimized parameters: distance, 10 cm; voltage, 10 kV; flow rate, 5 mL/h; collector rotating speed, 1800 rpm; and solution concentration, 10 wt%. Finally, these nanofibers with superior morphological properties may find application in biomedical, pharmaceutical, drug delivery and tissue scaffold for cell growth.

Original languageEnglish
Pages (from-to)1025-1038
Number of pages14
JournalIranian Polymer Journal (English Edition)
Volume24
Issue number12
DOIs
Publication statusPublished - 1 Dec 2015

Fingerprint

Polymethyl Methacrylate
Nanofibers
Thermodynamic properties
Mechanical properties
Electrospinning
Tissue Scaffolds
Fabrication
Dimethylformamide
Fibers
Mechanical testing
Cell growth
Sodium chloride
Drug delivery
Sodium Chloride
Field emission
Needles
Design of experiments
Drug products
Fourier transform infrared spectroscopy
Thermogravimetric analysis

Keywords

  • Aligned nanofibers
  • Box–Behnken design (BBD)
  • Electrospinning
  • Polymethyl methachrylate (PMMA)
  • Response surface methodology (RSM)

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Polymers and Plastics
  • Materials Chemistry

Cite this

Evaluation of thermal, morphological and mechanical properties of PMMA/NaCl/DMF electrospun nanofibers : an investigation through surface methodology approach. / Akhtar, Majid Niaz; Sulong, Abu Bakar; Karim, Saniah Ab; Azhari, Che Husna; Raza, M. R.

In: Iranian Polymer Journal (English Edition), Vol. 24, No. 12, 01.12.2015, p. 1025-1038.

Research output: Contribution to journalArticle

@article{2452cbc6c5604679b35b2b247539af82,
title = "Evaluation of thermal, morphological and mechanical properties of PMMA/NaCl/DMF electrospun nanofibers: an investigation through surface methodology approach",
abstract = "Electrospinning is an efficient, flexible and versatile method of producing nanofibers. The aims of this study are to fabrication and characterize electrospun nanofibers and evaluation of the electrospinning parameters that influence on the nanofibers properties. In this work, polymethylmetacrylate (PMMA) and sodium chloride were dissolved in dimethylformamide for fabrication of PMMA nanofibers through electrospinning. Differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and mechanical testing were used to measure the structure, morphology, diameter, orientation and strength of the nanofibers, respectively. The effect of electrospinning parameters on diameter, morphology and mechanical properties of nanofibers was also investigated. Collector rotating speed and gap distance were also found to be the most important factors that affected diameter and orientation of the nanofibers. Response surface methodology L46 and Box–Behnken experimental design were used to analyze and optimize the results. The theoretical and experimental study revealed that increasing the gap between collector and needle resulted in reduction of the electrospun nanofibers. However, fiber diameter was significantly influenced by decreasing the solution concentration and pump rate. Moreover, fibers with ~720 nm diameter and ~90 {\%} of orientation possessed an ultimate tensile strength of 1.4 MPa, which was exhibited at the following optimized parameters: distance, 10 cm; voltage, 10 kV; flow rate, 5 mL/h; collector rotating speed, 1800 rpm; and solution concentration, 10 wt{\%}. Finally, these nanofibers with superior morphological properties may find application in biomedical, pharmaceutical, drug delivery and tissue scaffold for cell growth.",
keywords = "Aligned nanofibers, Box–Behnken design (BBD), Electrospinning, Polymethyl methachrylate (PMMA), Response surface methodology (RSM)",
author = "Akhtar, {Majid Niaz} and Sulong, {Abu Bakar} and Karim, {Saniah Ab} and Azhari, {Che Husna} and Raza, {M. R.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1007/s13726-015-0390-8",
language = "English",
volume = "24",
pages = "1025--1038",
journal = "Iranian Polymer Journal (English Edition)",
issn = "1026-1265",
publisher = "Polymer Research Center of Iran",
number = "12",

}

TY - JOUR

T1 - Evaluation of thermal, morphological and mechanical properties of PMMA/NaCl/DMF electrospun nanofibers

T2 - an investigation through surface methodology approach

AU - Akhtar, Majid Niaz

AU - Sulong, Abu Bakar

AU - Karim, Saniah Ab

AU - Azhari, Che Husna

AU - Raza, M. R.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Electrospinning is an efficient, flexible and versatile method of producing nanofibers. The aims of this study are to fabrication and characterize electrospun nanofibers and evaluation of the electrospinning parameters that influence on the nanofibers properties. In this work, polymethylmetacrylate (PMMA) and sodium chloride were dissolved in dimethylformamide for fabrication of PMMA nanofibers through electrospinning. Differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and mechanical testing were used to measure the structure, morphology, diameter, orientation and strength of the nanofibers, respectively. The effect of electrospinning parameters on diameter, morphology and mechanical properties of nanofibers was also investigated. Collector rotating speed and gap distance were also found to be the most important factors that affected diameter and orientation of the nanofibers. Response surface methodology L46 and Box–Behnken experimental design were used to analyze and optimize the results. The theoretical and experimental study revealed that increasing the gap between collector and needle resulted in reduction of the electrospun nanofibers. However, fiber diameter was significantly influenced by decreasing the solution concentration and pump rate. Moreover, fibers with ~720 nm diameter and ~90 % of orientation possessed an ultimate tensile strength of 1.4 MPa, which was exhibited at the following optimized parameters: distance, 10 cm; voltage, 10 kV; flow rate, 5 mL/h; collector rotating speed, 1800 rpm; and solution concentration, 10 wt%. Finally, these nanofibers with superior morphological properties may find application in biomedical, pharmaceutical, drug delivery and tissue scaffold for cell growth.

AB - Electrospinning is an efficient, flexible and versatile method of producing nanofibers. The aims of this study are to fabrication and characterize electrospun nanofibers and evaluation of the electrospinning parameters that influence on the nanofibers properties. In this work, polymethylmetacrylate (PMMA) and sodium chloride were dissolved in dimethylformamide for fabrication of PMMA nanofibers through electrospinning. Differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, field emission scanning electron microscopy and mechanical testing were used to measure the structure, morphology, diameter, orientation and strength of the nanofibers, respectively. The effect of electrospinning parameters on diameter, morphology and mechanical properties of nanofibers was also investigated. Collector rotating speed and gap distance were also found to be the most important factors that affected diameter and orientation of the nanofibers. Response surface methodology L46 and Box–Behnken experimental design were used to analyze and optimize the results. The theoretical and experimental study revealed that increasing the gap between collector and needle resulted in reduction of the electrospun nanofibers. However, fiber diameter was significantly influenced by decreasing the solution concentration and pump rate. Moreover, fibers with ~720 nm diameter and ~90 % of orientation possessed an ultimate tensile strength of 1.4 MPa, which was exhibited at the following optimized parameters: distance, 10 cm; voltage, 10 kV; flow rate, 5 mL/h; collector rotating speed, 1800 rpm; and solution concentration, 10 wt%. Finally, these nanofibers with superior morphological properties may find application in biomedical, pharmaceutical, drug delivery and tissue scaffold for cell growth.

KW - Aligned nanofibers

KW - Box–Behnken design (BBD)

KW - Electrospinning

KW - Polymethyl methachrylate (PMMA)

KW - Response surface methodology (RSM)

UR - http://www.scopus.com/inward/record.url?scp=84947240030&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84947240030&partnerID=8YFLogxK

U2 - 10.1007/s13726-015-0390-8

DO - 10.1007/s13726-015-0390-8

M3 - Article

VL - 24

SP - 1025

EP - 1038

JO - Iranian Polymer Journal (English Edition)

JF - Iranian Polymer Journal (English Edition)

SN - 1026-1265

IS - 12

ER -