Evaluation of the effects of hydralazine on lipid peroxidation and atherogenesis

Kamsiah Jaarin, M. I. Nafeeza, S. K. Vasudevan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We studied the possible effects of hydralazine on lipid peroxidation and atherogenesis in sixteen male rabbits given a 2% cholesterol diet. Of these, eight were given intramuscular injections of hydralazine 1.25 mg kg-1 body weight twice daily for 10 weeks while the remaining eight served as controls. The serum malondialdehyde (MDA) and diene were significantly higher in the hydralazine group compared to the control group (P < 0.05). The Sudan IV positive intimal lesion, aortic tissue cholesterol, diene and MDA content were also significantly higher in the hydralazine group (P < 0.05). The increase in lipid peroxidation and atherogenesis suggest hydralazine as a possible oxidant.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalAsia Pacific Journal of Pharmacology
Volume10
Issue number2
Publication statusPublished - 1995

Fingerprint

Hydralazine
Lipid Peroxidation
Atherosclerosis
Malondialdehyde
Cholesterol
Tunica Intima
Intramuscular Injections
Oxidants
Body Weight
Diet
Rabbits
Control Groups
Serum

Keywords

  • high cholesterol diet
  • hydralazine
  • lipid peroxidation

ASJC Scopus subject areas

  • Pharmacology

Cite this

Evaluation of the effects of hydralazine on lipid peroxidation and atherogenesis. / Jaarin, Kamsiah; Nafeeza, M. I.; Vasudevan, S. K.

In: Asia Pacific Journal of Pharmacology, Vol. 10, No. 2, 1995, p. 59-63.

Research output: Contribution to journalArticle

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