Evaluation of Power Doppler Ultrasonography for prostate biopsy in men with elevated serum prostate specific antigen levels

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Abstract

Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalClinica Terapeutica
Volume163
Issue number3
Publication statusPublished - 2012

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Doppler Ultrasonography
Prostate-Specific Antigen
Prostate
Biopsy
Serum
Prostatic Neoplasms
Adenocarcinoma
Perfusion
Sensitivity and Specificity

Keywords

  • Biopsy
  • Cancer
  • Doppler
  • Prostate
  • Ultrasound

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Evaluation of Power Doppler Ultrasonography for prostate biopsy in men with elevated serum prostate specific antigen levels",
abstract = "Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4{\%} and abnormal accumulation on PDU signal was identified in 96.7{\%} of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7{\%} of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7{\%}, 24.5{\%} and 96.4{\%} respectively, and PDU guided biopsies were 66.7{\%}, 24.5{\%}, 19.4{\%} and 73{\%} respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.",
keywords = "Biopsy, Cancer, Doppler, Prostate, Ultrasound",
author = "Ho, {Chee Kong Christopher} and Khor, {T. W.} and Praveen Singam and Goh, {Eng Hong} and Tan, {Guan Hee} and B. Bahadzor and {Md. Zainuddin}, Zulkifli",
year = "2012",
language = "English",
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pages = "211--214",
journal = "Clinica Terapeutica",
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T1 - Evaluation of Power Doppler Ultrasonography for prostate biopsy in men with elevated serum prostate specific antigen levels

AU - Ho, Chee Kong Christopher

AU - Khor, T. W.

AU - Singam, Praveen

AU - Goh, Eng Hong

AU - Tan, Guan Hee

AU - Bahadzor, B.

AU - Md. Zainuddin, Zulkifli

PY - 2012

Y1 - 2012

N2 - Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.

AB - Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.

KW - Biopsy

KW - Cancer

KW - Doppler

KW - Prostate

KW - Ultrasound

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