Abstract
Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 211-214 |
| Number of pages | 4 |
| Journal | Clinica Terapeutica |
| Volume | 163 |
| Issue number | 3 |
| Publication status | Published - 2012 |
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Keywords
- Biopsy
- Cancer
- Doppler
- Prostate
- Ultrasound
ASJC Scopus subject areas
- Medicine(all)
Cite this
Evaluation of Power Doppler Ultrasonography for prostate biopsy in men with elevated serum prostate specific antigen levels. / Ho, Chee Kong Christopher; Khor, T. W.; Singam, Praveen; Goh, Eng Hong; Tan, Guan Hee; Bahadzor, B.; Md. Zainuddin, Zulkifli.
In: Clinica Terapeutica, Vol. 163, No. 3, 2012, p. 211-214.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Evaluation of Power Doppler Ultrasonography for prostate biopsy in men with elevated serum prostate specific antigen levels
AU - Ho, Chee Kong Christopher
AU - Khor, T. W.
AU - Singam, Praveen
AU - Goh, Eng Hong
AU - Tan, Guan Hee
AU - Bahadzor, B.
AU - Md. Zainuddin, Zulkifli
PY - 2012
Y1 - 2012
N2 - Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.
AB - Objectives. To evaluate power doppler ultrasonography (PDU) - directed prostate biopsy in patients with elevated serum prostate specific antigen (PSA) levels. Materials and Methods. Men with serum total PSA levels of more than 4 ng/ml undergoing biopsy for the first time were included. Greyscale transrectal ultrasound (TRUS) and PDU were performed. PDU signal on vascularity accumulation and perfusion characteristics were recorded and graded as normal or abnormal in the peripheral zone of the prostate. Abnormalities were defined on transverse image as radial or arc hypervascularities. A biopsy regime based on Vienna-normogram was performed in all patients. Results. Overall, prostate adenocarcinoma detection rate was 21.4% and abnormal accumulation on PDU signal was identified in 96.7% of those patients (p = 0.01). PDU directed prostate biopsies were positive in 66.7% of the patients with prostate cancer. The sensitivity, specificity, positive predictive value and negative predictive value of PDU signal alone for prostate cancer detection was 96.7%, 24.5% and 96.4% respectively, and PDU guided biopsies were 66.7%, 24.5%, 19.4% and 73% respectively. Conclusions. The high sensitivity and negative predictive value of PDU makes it useful as an aid for TRUS biopsy in selected patient with previous negative biopsies at risk of harbouring prostate cancer.
KW - Biopsy
KW - Cancer
KW - Doppler
KW - Prostate
KW - Ultrasound
UR - http://www.scopus.com/inward/record.url?scp=84864017886&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864017886&partnerID=8YFLogxK
M3 - Article
C2 - 22964693
AN - SCOPUS:84864017886
VL - 163
SP - 211
EP - 214
JO - Clinica Terapeutica
JF - Clinica Terapeutica
SN - 0009-9074
IS - 3
ER -