Evaluation of appropriate use of antifungal therapy in a tertiary care hospital

Farida Hanim Islahudin, Siti Fatimah Radiyah Mohd

Research output: Contribution to journalArticle

Abstract

Objective: Appropriate use of antifungal therapy has becoming a worrying issue since misuse of antifungal may contribute to the emergence and global increase in antifungal resistance. Use of a more standardized approach in identifying appropriate use is required in an attempt to reduce the risk of resistance. The study assesses the appropriate use of antifungal therapy in a local tertiary care hospital. Methods: It was conducted as a retrospective study based on patients prescribed antifungals for the past 1 year. Results: The A total of 135 patients were included in the study. The majority of the patients were Malay (n=77, 57%), followed by Chinese (n=39, 28.9%), Indians (n=11, 8.1%) and others (n=8, 5.9%). The mean age of patients was 57.5±16.58 years. The mean duration of admission was 29.39±21.85. Overall assessment of antifungal use demonstrated that antifungal therapy was appropriate in 85 (44.7%) cases, debatable in 34 (17.9%) and inappropriate in 71 (37.3%) cases (p=0.000015). There was a significantly high number of inappropriate azole use (p=0.0001) in the study population. The most common type of azole used was fluconazole. Further analyses identified that demographic factors that affected the duration of admission of those that survived were age, number of medication and number of antifungals. Duration of admission increased with increasing age (r=0.219, p=0.044), increase in medication (r=0.333, p=0.0019) and increase in number of antifungal treatment given (r=0.239, p=0.027). Conclusion: This work demonstrated the need for a closer or more stringent efforts in reducing inappropriate antifungal use.

Original languageEnglish
Pages (from-to)195-199
Number of pages5
JournalAsian Journal of Pharmaceutical and Clinical Research
Volume8
Issue number4
Publication statusPublished - 2015

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Tertiary Healthcare
Tertiary Care Centers
Azoles
Fluconazole
Therapeutics
Retrospective Studies
Demography
Population

Keywords

  • Antifungal therapy
  • Appropriateness
  • Fungal infections

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology
  • Pharmacology (medical)

Cite this

Evaluation of appropriate use of antifungal therapy in a tertiary care hospital. / Islahudin, Farida Hanim; Mohd, Siti Fatimah Radiyah.

In: Asian Journal of Pharmaceutical and Clinical Research, Vol. 8, No. 4, 2015, p. 195-199.

Research output: Contribution to journalArticle

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