Evaluation of antimicrobial activities of organotin (IV) alkylphenyl dithiocarbamate compounds

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5 Citations (Scopus)

Abstract

Antibiotic resistance is a global challenge to the populations and pathogenic bacteria tends to be multiresistant towards a vast majority of antibiotics. The organotin (IV) compounds have proven to have an active biological activity as antimicrobial agent. Two series of a new compounds namely organotin (IV) ethylphenyl dithiocarbamate and butylphenyldithiocarbamate which contained 6 compounds have been tested for their antimicrobial activity using disk diffusion and microdilution tests. These compounds were tested against various microbes namely Bacillus cereus, Bacillus subtilis, Methicillin-Resistant Staphylococcus Aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter baumannii, Escherichia coli, Klebsiella sp., Shigellasonnei, Vibrio cholerae, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Microdilution test was carried out using two-fold dilution with the highest concentration of 5 mg mL-1. Results showed that compound 3 and 6 have the antimicrobial activity towards most of bacteria and fungi tested. The lowest Minimum Inhibitory Concentration (MIC) value was obtained at 39 μg mL-1 for compound 3 against V. cholerae and compound 6 against A. baumannii. Nevertheless, bacteriostatic or fungistatic effect was obtained for all compounds. In conclusion, triphenyltin (IV) dithiocarbamate compounds have a potential to act as an antimicrob agent.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalAsian Journal of Applied Sciences
Volume8
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Organotin Compounds
Acinetobacter baumannii
Vibrio cholerae
Staphylococcal Pneumonia
Bacteria
Aspergillus fumigatus
Bacillus cereus
Klebsiella
Aspergillus niger
Microbial Sensitivity Tests
Methicillin-Resistant Staphylococcus aureus
Microbial Drug Resistance
Anti-Infective Agents
Streptococcus pneumoniae
Bacillus subtilis
Candida albicans
Saccharomyces cerevisiae
Fungi
Escherichia coli
Anti-Bacterial Agents

Keywords

  • Antimicrobial activity
  • Disk diffusion
  • Dithiocarbamate
  • Microdilution
  • Organotin (IV)

ASJC Scopus subject areas

  • General

Cite this

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abstract = "Antibiotic resistance is a global challenge to the populations and pathogenic bacteria tends to be multiresistant towards a vast majority of antibiotics. The organotin (IV) compounds have proven to have an active biological activity as antimicrobial agent. Two series of a new compounds namely organotin (IV) ethylphenyl dithiocarbamate and butylphenyldithiocarbamate which contained 6 compounds have been tested for their antimicrobial activity using disk diffusion and microdilution tests. These compounds were tested against various microbes namely Bacillus cereus, Bacillus subtilis, Methicillin-Resistant Staphylococcus Aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter baumannii, Escherichia coli, Klebsiella sp., Shigellasonnei, Vibrio cholerae, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Microdilution test was carried out using two-fold dilution with the highest concentration of 5 mg mL-1. Results showed that compound 3 and 6 have the antimicrobial activity towards most of bacteria and fungi tested. The lowest Minimum Inhibitory Concentration (MIC) value was obtained at 39 μg mL-1 for compound 3 against V. cholerae and compound 6 against A. baumannii. Nevertheless, bacteriostatic or fungistatic effect was obtained for all compounds. In conclusion, triphenyltin (IV) dithiocarbamate compounds have a potential to act as an antimicrob agent.",
keywords = "Antimicrobial activity, Disk diffusion, Dithiocarbamate, Microdilution, Organotin (IV)",
author = "Normah Awang and Mohktar, {Siti Munirah} and {Mohamad Zin}, Noraziah and {Nurul Farahana}, Kamaludin",
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AU - Mohamad Zin, Noraziah

AU - Nurul Farahana, Kamaludin

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N2 - Antibiotic resistance is a global challenge to the populations and pathogenic bacteria tends to be multiresistant towards a vast majority of antibiotics. The organotin (IV) compounds have proven to have an active biological activity as antimicrobial agent. Two series of a new compounds namely organotin (IV) ethylphenyl dithiocarbamate and butylphenyldithiocarbamate which contained 6 compounds have been tested for their antimicrobial activity using disk diffusion and microdilution tests. These compounds were tested against various microbes namely Bacillus cereus, Bacillus subtilis, Methicillin-Resistant Staphylococcus Aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter baumannii, Escherichia coli, Klebsiella sp., Shigellasonnei, Vibrio cholerae, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Microdilution test was carried out using two-fold dilution with the highest concentration of 5 mg mL-1. Results showed that compound 3 and 6 have the antimicrobial activity towards most of bacteria and fungi tested. The lowest Minimum Inhibitory Concentration (MIC) value was obtained at 39 μg mL-1 for compound 3 against V. cholerae and compound 6 against A. baumannii. Nevertheless, bacteriostatic or fungistatic effect was obtained for all compounds. In conclusion, triphenyltin (IV) dithiocarbamate compounds have a potential to act as an antimicrob agent.

AB - Antibiotic resistance is a global challenge to the populations and pathogenic bacteria tends to be multiresistant towards a vast majority of antibiotics. The organotin (IV) compounds have proven to have an active biological activity as antimicrobial agent. Two series of a new compounds namely organotin (IV) ethylphenyl dithiocarbamate and butylphenyldithiocarbamate which contained 6 compounds have been tested for their antimicrobial activity using disk diffusion and microdilution tests. These compounds were tested against various microbes namely Bacillus cereus, Bacillus subtilis, Methicillin-Resistant Staphylococcus Aureus (MRSA), Staphylococcus aureus, Streptococcus pneumonia, Acinetobacter baumannii, Escherichia coli, Klebsiella sp., Shigellasonnei, Vibrio cholerae, Aspergillus fumigatus, Aspergillus niger, Candida albicans and Saccharomyces cerevisiae. Microdilution test was carried out using two-fold dilution with the highest concentration of 5 mg mL-1. Results showed that compound 3 and 6 have the antimicrobial activity towards most of bacteria and fungi tested. The lowest Minimum Inhibitory Concentration (MIC) value was obtained at 39 μg mL-1 for compound 3 against V. cholerae and compound 6 against A. baumannii. Nevertheless, bacteriostatic or fungistatic effect was obtained for all compounds. In conclusion, triphenyltin (IV) dithiocarbamate compounds have a potential to act as an antimicrob agent.

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