Eurycoma longifolia

Medicinal plant in the prevention and treatment of male osteoporosis due to androgen deficiency

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Osteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis.

Original languageEnglish
Article number125761
JournalEvidence-based Complementary and Alternative Medicine
Volume2012
DOIs
Publication statusPublished - 2012

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Eurycoma
Medicinal Plants
Androgens
Osteoporosis
Testosterone
Therapeutics
Hypogonadism
Bone Remodeling
Phytochemicals
Osteoclasts
Osteoblasts
Apoptosis
Bone and Bones
Mortality
Health

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

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title = "Eurycoma longifolia: Medicinal plant in the prevention and treatment of male osteoporosis due to androgen deficiency",
abstract = "Osteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis.",
author = "{Mohd Effendy}, Nadia and Norazlina Mohamed and Norliza Muhammad and {Naina Mohamed}, Isa and Shuid, {Ahmad Nazrun}",
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AU - Muhammad, Norliza

AU - Naina Mohamed, Isa

AU - Shuid, Ahmad Nazrun

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AB - Osteoporosis in elderly men is now becoming an alarming health issue due to its relation with a higher mortality rate compared to osteoporosis in women. Androgen deficiency (hypogonadism) is one of the major factors of male osteoporosis and it can be treated with testosterone replacement therapy (TRT). However, one medicinal plant, Eurycoma longifolia Jack (EL), can be used as an alternative treatment to prevent and treat male osteoporosis without causing the side effects associated with TRT. EL exerts proandrogenic effects that enhance testosterone level, as well as stimulate osteoblast proliferation and osteoclast apoptosis. This will maintain bone remodelling activity and reduce bone loss. Phytochemical components of EL may also prevent osteoporosis via its antioxidative property. Hence, EL has the potential as a complementary treatment for male osteoporosis.

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