Eurycoma Longifolia in Radix™ for the treatment of ethanol-induced gastric lesion in rats

Qodriyah Mohd Saad, A. Y. Asmadi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effect of treatment with Radix™ on ethanol-induced gastric lesions was investigated. The main ingredient of Radix™ is Eurycoma longifolia. Twenty-four rats of the Sprague-Dawley species were randomly divided into four groups. Three groups were given 0.5 mL 100% ethanol orally. Another group was used as a control and was given only distilled water orally (control). After 6 h all the rats were fed with normal diet. One group that was administered with ethanol was only given distilled water orally (no treatment). Another two groups that were administered with ethanol were treated with oral Radix™ 0.128 mg g-1 b.wt. (Radix) and oral ranitidine 21.4 mg kg-1 b.wt. (Ranitidine), respectively. After one week, all the rats were fasted overnight and sacrificed. The stomach was isolated and examined for the presence and severity of gastric lesions. Measurements for malondialdehyde content and gastric acid concentration were also done. It is found that the ulcer index was lower in the Radix and ranitidine group compared to the no treatment group whereas in the control group there was no lesion. There was no difference in ulcer index between the Radix and ranitidine group. The gastric MDA content was significantly higher in all the groups that were induced with ethanol compared to the control group but no difference between all the ethanol-induced groups. There was no difference in the gastric acid concentration in all groups. Hence it is concluded that Eurycoma longifolia in Radix™ is as effective as ranitidine in the treatment of ethanol-induced gastric lesions in rats.

Original languageEnglish
Pages (from-to)1815-1818
Number of pages4
JournalPakistan Journal of Biological Sciences
Volume16
Issue number23
DOIs
Publication statusPublished - 2013

Fingerprint

Eurycoma longifolia
lesions (animal)
stomach
ethanol
rats
gastric acid
mouth
malondialdehyde
ingredients
water

Keywords

  • Ethanol
  • Eurycoma longifolia
  • Gastric acid
  • Malondialdehyde
  • Ulcer index

ASJC Scopus subject areas

  • Agronomy and Crop Science

Cite this

Eurycoma Longifolia in Radix™ for the treatment of ethanol-induced gastric lesion in rats. / Mohd Saad, Qodriyah; Asmadi, A. Y.

In: Pakistan Journal of Biological Sciences, Vol. 16, No. 23, 2013, p. 1815-1818.

Research output: Contribution to journalArticle

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