Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna: a review

Roza Dianita, Ibrahim Jantan

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

CONTEXT: The genus Premna (Lamiaceae), distributed throughout tropical and subtropical Asia, Africa, Australia and the Pacific Islands, is used in folk medicine primarily to treat inflammation, immune-related diseases, stomach disorders, wound healing, and skin diseases.

OBJECTIVES: This review exhaustively gathers available information on ethnopharmacological uses, phytochemistry, and bioactivity studies on more than 20 species of Premna and critically analyzes the reports to provide the perspectives and directions for future research for the plants as potential source of drug leads and pharmaceutical agents.

METHODS: A literature search was performed on Premna species based on books of herbal medicine, major scientific databases including Chemical Abstract, Pubmed, SciFinder, Springerlink, Science Direct, Scopus, the Web of Science, Google Scholar, and ethnobotanical databases.

RESULTS: More than 250 compounds have been isolated and identified from Premna species, comprising of diterpenoids, iridoid glycosides, and flavonoids as the most common secondary metabolites, followed by sesquiterpenes, lignans, phenylethanoids, megastigmanes, glyceroglycolipids, and ceramides. Many in vitro and in vivo studies have been conducted to evaluate the biological and pharmacological properties of the extracts, and isolated compounds of Premna species with antimicrobial, antioxidant, anti-inflammatory, immunomodulatory, antihyperglycaemia, and cytotoxic activities.

CONCLUSION: The bioactive compounds responsible for the bioactivities of most plants have not been well identified as the reported in vivo pharmacological studies were mostly carried out on the crude extracts. The isolated bioactive components should also be further subjected to more preclinical studies and elaborate toxicity study before clinical trials can be pursued.

Original languageEnglish
Pages (from-to)1715-1739
Number of pages25
JournalPharmaceutical Biology
Volume55
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Iridoid Glycosides
Chemical Databases
Norisoprenoids
Pharmacology
Pacific Islands
Lamiaceae
Lignans
Sesquiterpenes
Herbal Medicine
Diterpenes
Ceramides
Immune System Diseases
Traditional Medicine
Complex Mixtures
Skin Diseases
Flavonoids
PubMed
Pharmaceutical Preparations
Wound Healing
Stomach

Keywords

  • anti-inflammatory
  • antimicrobial
  • cytotoxic
  • diterpenes
  • flavonoids
  • immunomodulatory
  • iridoid glycosides
  • Traditional uses

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna : a review. / Dianita, Roza; Jantan, Ibrahim.

In: Pharmaceutical Biology, Vol. 55, No. 1, 01.12.2017, p. 1715-1739.

Research output: Contribution to journalReview article

Dianita, Roza ; Jantan, Ibrahim. / Ethnomedicinal uses, phytochemistry and pharmacological aspects of the genus Premna : a review. In: Pharmaceutical Biology. 2017 ; Vol. 55, No. 1. pp. 1715-1739.
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