Estrogen receptor-negative breast ductal carcinoma: Clinicopathological features and Mib-1 (Ki-67) proliferative index association

Noorasmaliza MdPaiman, Siti Aishah Md Ali, Reena Rahayu Md Zain, Meor Zamari Meor Kamal, Wan Anna Md Amin, Mohan Nallusamy, Pavitratha Puspanathan, Rohaizak Muhammad, Sharifa Ezat Wan Puteh, Srijit Das

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.

Original languageEnglish
Article numbere89172
JournalPLoS One
Volume9
Issue number2
DOIs
Publication statusPublished - 28 Feb 2014

Fingerprint

Carcinoma, Ductal, Breast
Estrogen Receptors
breast neoplasms
Tumors
Breast Neoplasms
Ductal Carcinoma
neoplasms
carcinoma
Neoplasms
estrogen receptors

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Estrogen receptor-negative breast ductal carcinoma : Clinicopathological features and Mib-1 (Ki-67) proliferative index association. / MdPaiman, Noorasmaliza; Md Ali, Siti Aishah; Md Zain, Reena Rahayu; Kamal, Meor Zamari Meor; Md Amin, Wan Anna; Nallusamy, Mohan; Puspanathan, Pavitratha; Muhammad, Rohaizak; Wan Puteh, Sharifa Ezat; Das, Srijit.

In: PLoS One, Vol. 9, No. 2, e89172, 28.02.2014.

Research output: Contribution to journalArticle

MdPaiman, Noorasmaliza ; Md Ali, Siti Aishah ; Md Zain, Reena Rahayu ; Kamal, Meor Zamari Meor ; Md Amin, Wan Anna ; Nallusamy, Mohan ; Puspanathan, Pavitratha ; Muhammad, Rohaizak ; Wan Puteh, Sharifa Ezat ; Das, Srijit. / Estrogen receptor-negative breast ductal carcinoma : Clinicopathological features and Mib-1 (Ki-67) proliferative index association. In: PLoS One. 2014 ; Vol. 9, No. 2.
@article{101691f3740840c6a69e91dd3b719502,
title = "Estrogen receptor-negative breast ductal carcinoma: Clinicopathological features and Mib-1 (Ki-67) proliferative index association",
abstract = "Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20{\%}) was observed in 63 (63.6{\%}) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6{\%}). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.",
author = "Noorasmaliza MdPaiman and {Md Ali}, {Siti Aishah} and {Md Zain}, {Reena Rahayu} and Kamal, {Meor Zamari Meor} and {Md Amin}, {Wan Anna} and Mohan Nallusamy and Pavitratha Puspanathan and Rohaizak Muhammad and {Wan Puteh}, {Sharifa Ezat} and Srijit Das",
year = "2014",
month = "2",
day = "28",
doi = "10.1371/journal.pone.0089172",
language = "English",
volume = "9",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "2",

}

TY - JOUR

T1 - Estrogen receptor-negative breast ductal carcinoma

T2 - Clinicopathological features and Mib-1 (Ki-67) proliferative index association

AU - MdPaiman, Noorasmaliza

AU - Md Ali, Siti Aishah

AU - Md Zain, Reena Rahayu

AU - Kamal, Meor Zamari Meor

AU - Md Amin, Wan Anna

AU - Nallusamy, Mohan

AU - Puspanathan, Pavitratha

AU - Muhammad, Rohaizak

AU - Wan Puteh, Sharifa Ezat

AU - Das, Srijit

PY - 2014/2/28

Y1 - 2014/2/28

N2 - Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.

AB - Breast cancer estrogen receptor (ER) status is one of the strong additional factors in predicting response of patients towards hormonal treatment. The main aim of this study was to assess the morphological characteristics and proliferative activity using MIB-1(Ki-67) of estrogen receptor negative invasive breast ductal carcinoma (NOS type) as well as to correlate these features with clinicopathological data. We also aim to study the expression of c-erbB2 in ER negative breast tumors. High proliferative rate (MIB-1 above 20%) was observed in 63 (63.6%) of 99 ER negative tumors and that these tumors were associated with high expression of c-erbB2 (57.6%). We observed that MIB-1 is a reliable independent prognostic indicator for ER negative infiltrating ductal carcinoma in this study.

UR - http://www.scopus.com/inward/record.url?scp=84896504677&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84896504677&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0089172

DO - 10.1371/journal.pone.0089172

M3 - Article

C2 - 24586570

AN - SCOPUS:84896504677

VL - 9

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 2

M1 - e89172

ER -