Estimation of glomerular filtration rate using serum cystatin C in overweight and obese subjects

M. N. Norli Marwyne, C. Y. Loo, Abdul Halim Abdul Gafor, K. Norella, T. Sulaiman, Zaleha Md Isa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Obesity and overweight are strong independent risk factors for chronic kidney disease (CKD). Using serum creatinine-based estimated glomerular filtration rate (eGFR) equations in these subjects may be inaccurate. On the other hand, cystatin C-based eGFR equations may overestimate CKD prevalence as recent findings suggest an association of cystatin C with obesity. The objective of this study was to assess the accuracy of a cystatin C-based eGFR equation compared to two creatinine -based eGFR equations in overweight and obese subjects. Methods: This was a prospective cross-sectional study which recruited healthy volunteers aged 18-55 years with a body mass index (BMI) ≥ 23kg/m 2 (Asia Pacific Guidelines). Their renal profiles, serum cystatin C and 99m technetium diethylene triamine pentacetic acid ( 99mTc-DTPA) scans were performed on the same day. The correlations and accuracy of the creatinine-based and cystatin C-based eGFR equations with the ⁹⁹mTc-DTPA GFR were determined. Results: One hundred and one subjects with a median age of 30.0 (27.0-43.5) years and mean BMI of 28.7 ± 4.5 kg/m2 were recruited. The cystatin C-based eGFR equation showed the best correlation with the 99mTc-DTPA GFR (r=0.526, p=0.001) and was more accurate in measuring abnormal GFR compared to the creatinine-based eGFR equations. Conclusion: Our study showed that the cystatin C-based eGFR equation was more accurate, sensitive and specific in overweight and obese subjects compared to the creatininebased eGFR equations.

Original languageEnglish
Pages (from-to)313-317
Number of pages5
JournalMedical Journal of Malaysia
Volume66
Issue number4
Publication statusPublished - Oct 2011

Fingerprint

Cystatin C
Glomerular Filtration Rate
Serum
Creatinine
Technetium
Chronic Renal Insufficiency
Body Mass Index
Obesity
Pentetic Acid
Acids
Healthy Volunteers
Cross-Sectional Studies
Guidelines
Kidney

Keywords

  • Chronic kidney disease
  • Creatinine
  • Cystatin C
  • Estimated glomerular filtration rate
  • Obese
  • Overweight

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Estimation of glomerular filtration rate using serum cystatin C in overweight and obese subjects. / Norli Marwyne, M. N.; Loo, C. Y.; Abdul Gafor, Abdul Halim; Norella, K.; Sulaiman, T.; Md Isa, Zaleha.

In: Medical Journal of Malaysia, Vol. 66, No. 4, 10.2011, p. 313-317.

Research output: Contribution to journalArticle

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N2 - Background: Obesity and overweight are strong independent risk factors for chronic kidney disease (CKD). Using serum creatinine-based estimated glomerular filtration rate (eGFR) equations in these subjects may be inaccurate. On the other hand, cystatin C-based eGFR equations may overestimate CKD prevalence as recent findings suggest an association of cystatin C with obesity. The objective of this study was to assess the accuracy of a cystatin C-based eGFR equation compared to two creatinine -based eGFR equations in overweight and obese subjects. Methods: This was a prospective cross-sectional study which recruited healthy volunteers aged 18-55 years with a body mass index (BMI) ≥ 23kg/m 2 (Asia Pacific Guidelines). Their renal profiles, serum cystatin C and 99m technetium diethylene triamine pentacetic acid ( 99mTc-DTPA) scans were performed on the same day. The correlations and accuracy of the creatinine-based and cystatin C-based eGFR equations with the ⁹⁹mTc-DTPA GFR were determined. Results: One hundred and one subjects with a median age of 30.0 (27.0-43.5) years and mean BMI of 28.7 ± 4.5 kg/m2 were recruited. The cystatin C-based eGFR equation showed the best correlation with the 99mTc-DTPA GFR (r=0.526, p=0.001) and was more accurate in measuring abnormal GFR compared to the creatinine-based eGFR equations. Conclusion: Our study showed that the cystatin C-based eGFR equation was more accurate, sensitive and specific in overweight and obese subjects compared to the creatininebased eGFR equations.

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