Estimating glomerular filtration rate in overweight and obese malaysian subjects

Nor Hayati Shaharudin, Abdul Halim Abdul Gafor, Soehardy Zainudin, Norella C T Kong, Aini Abdul Aziz, Shamsul Azhar Shah

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and Aims: Overweight and obesity are significant risk factors for chronic kidney disease (CKD). Glomerular filtration rate (GFR) is the best index of renal function. We evaluated the accuracy of the Cockroft-Gault, MDRD and modified MDRD formulae in predicting GFR in overweight and obese subjects and also determined the relationship between Body Mass Index (BMI), weight and GFR. Methods: Healthy volunteers with BMI ≥ 23kg/m2 were recruited and subjected to blood and urine investigations, renal ultrasonography and 99mTc-DTPA renal scan. The correlation, accuracy and precision of the eGFR derived from each formula were compared with reference GFR as determined by 99mTc-DTPA. Results: A total of 101 subjects with a median weight of 74.0kg (68.0-84.7) and median BMI of 29.6 kg/m2 (27.2-33.2) were recruited. Their mean GFR 99mTc-DTPA was 120.3± 24.5ml/mm/1.73m2. Although the eGFRs derived from all formulae correlated with GFR 99mTc-DTPA, only those derived from the MDRD and modified MDRD had small biases and better precision in estimating GFR. While GFR significantly correlated with the subjects' weight (p=0.036), it didn't with their BMI (p=0.302). Conclusions: The MDRD-based formulae were better in estimating GFR in overweight and obese Malaysian subjects. GFR correlated with subjects' weight rather than BMI.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
JournalNephro-Urology Monthly
Volume3
Issue number1
Publication statusPublished - 2011

Fingerprint

Glomerular Filtration Rate
Pentetic Acid
Body Mass Index
Weights and Measures
Kidney
Chronic Renal Insufficiency
Ultrasonography
Healthy Volunteers
Obesity
Urine

Keywords

  • CKD
  • Cockcroft-gault
  • eGFR
  • MDRD
  • Obese
  • Overweight

ASJC Scopus subject areas

  • Urology

Cite this

Estimating glomerular filtration rate in overweight and obese malaysian subjects. / Shaharudin, Nor Hayati; Abdul Gafor, Abdul Halim; Zainudin, Soehardy; Kong, Norella C T; Aziz, Aini Abdul; Shah, Shamsul Azhar.

In: Nephro-Urology Monthly, Vol. 3, No. 1, 2011, p. 15-22.

Research output: Contribution to journalArticle

Shaharudin, Nor Hayati ; Abdul Gafor, Abdul Halim ; Zainudin, Soehardy ; Kong, Norella C T ; Aziz, Aini Abdul ; Shah, Shamsul Azhar. / Estimating glomerular filtration rate in overweight and obese malaysian subjects. In: Nephro-Urology Monthly. 2011 ; Vol. 3, No. 1. pp. 15-22.
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AU - Aziz, Aini Abdul

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KW - CKD

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