Estimating glomerular filtration rate in adult kidney transplant recipients in the Asian population

Lydia Kamaruzaman, Rozita Mohd, Faizah Mohd Zaki, Rozita Hod, Aini Ab Aziz

Research output: Contribution to journalArticle

Abstract

Estimation of glomerular filtration rate (GFR) in renal transplant patients is often assessed by application of creatinine-based equations. The aim was to correlate the estimated GFR (eGFR) using creatinine-based equations [Cockroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Nankivell] with gold standard 51Cr-EDTA in kidney transplant patients in the Asian population. This is a single-center, cross-sectional study involving adult renal transplant patients. Background demographic data, medications, office blood pressure, and baseline investigations were taken. Correlations between measured GFR and eGFR were analyzed and Pearson's correlation coefficients, bias, and accuracy were assessed. Thirty-seven renal transplant patients with a mean age of 46 ± 13 years were recruited. Majority were Chinese (68%), Malay (24%), and Indian (8%). The median duration of the transplant was 84 (interquartile range 60,132) months. The mean measured GFR was 71 ± 21 mL/min/1.73 m2. Cockroft-Gault and CKD-EPI has the best correlation with 51Cr-EDTA with Pearson correlation coefficients of 0.733 (P <0.001) and 0.711 (P < 0.001), respectively. All formulae showed >80% accuracy with eGFR lies between 30% of the measured value. CKD-EPI and MDRD had the greatest accuracy with 89.2% each. Clinician may use any of these three serum creatinine-based equations to estimate GFR in kidney transplant recipients.

Original languageEnglish
Pages (from-to)587-596
Number of pages10
JournalSaudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Volume30
Issue number3
DOIs
Publication statusPublished - 1 May 2019

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Glomerular Filtration Rate
Kidney
Transplants
Population
Chronic Renal Insufficiency
Diet Therapy
Creatinine
Epidemiology
Edetic Acid
Transplant Recipients
Cross-Sectional Studies
Demography
Blood Pressure
Serum

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Estimating glomerular filtration rate in adult kidney transplant recipients in the Asian population",
abstract = "Estimation of glomerular filtration rate (GFR) in renal transplant patients is often assessed by application of creatinine-based equations. The aim was to correlate the estimated GFR (eGFR) using creatinine-based equations [Cockroft-Gault, Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), Nankivell] with gold standard 51Cr-EDTA in kidney transplant patients in the Asian population. This is a single-center, cross-sectional study involving adult renal transplant patients. Background demographic data, medications, office blood pressure, and baseline investigations were taken. Correlations between measured GFR and eGFR were analyzed and Pearson's correlation coefficients, bias, and accuracy were assessed. Thirty-seven renal transplant patients with a mean age of 46 ± 13 years were recruited. Majority were Chinese (68{\%}), Malay (24{\%}), and Indian (8{\%}). The median duration of the transplant was 84 (interquartile range 60,132) months. The mean measured GFR was 71 ± 21 mL/min/1.73 m2. Cockroft-Gault and CKD-EPI has the best correlation with 51Cr-EDTA with Pearson correlation coefficients of 0.733 (P <0.001) and 0.711 (P < 0.001), respectively. All formulae showed >80{\%} accuracy with eGFR lies between 30{\%} of the measured value. CKD-EPI and MDRD had the greatest accuracy with 89.2{\%} each. Clinician may use any of these three serum creatinine-based equations to estimate GFR in kidney transplant recipients.",
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