Epstein-barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma

A distinct entity

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management. We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excision was performed and examination confirmed PSNPC with positive Epstein Barr virus in-situ hybridisation. Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.

Original languageEnglish
Pages (from-to)70-73
Number of pages4
JournalEastern Journal of Medicine
Volume22
Issue number2
DOIs
Publication statusPublished - 2017

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Human Herpesvirus 4
Nasal Obstruction
In Situ Hybridization
Nasopharyngeal carcinoma
Sinonasal undifferentiated carcinoma
Neoplasms

Keywords

  • Epstein-Barr virus
  • Nasopharynx
  • Paranasal sinus
  • Sinonasal
  • Undifferentiated carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Epstein-barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity",
abstract = "Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management. We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excision was performed and examination confirmed PSNPC with positive Epstein Barr virus in-situ hybridisation. Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.",
keywords = "Epstein-Barr virus, Nasopharynx, Paranasal sinus, Sinonasal, Undifferentiated carcinoma",
author = "Zahedi, {Farah Dayana} and Hussin, {Nik Mohd Hazleigh Nik} and Salina Husain and {Athi Kumar}, {Ramesh Kumar} and Gendeh, {Balwant Singh}",
year = "2017",
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pages = "70--73",
journal = "Eastern Journal of Medicine",
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TY - JOUR

T1 - Epstein-barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma

T2 - A distinct entity

AU - Zahedi, Farah Dayana

AU - Hussin, Nik Mohd Hazleigh Nik

AU - Husain, Salina

AU - Athi Kumar, Ramesh Kumar

AU - Gendeh, Balwant Singh

PY - 2017

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AB - Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management. We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excision was performed and examination confirmed PSNPC with positive Epstein Barr virus in-situ hybridisation. Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.

KW - Epstein-Barr virus

KW - Nasopharynx

KW - Paranasal sinus

KW - Sinonasal

KW - Undifferentiated carcinoma

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