Endonasal endoscopic transsphenoidal pituitary surgery for pituitary adenoma

A retrospective analysis of surgical outcome

Mohd Sazafi Mohd Saad, Balwant Singh Gendeh, Salina Husain

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of this retrospective joint rhino-neurosurgical study from January 1998 until September 2009 is to document the demographic data, clinical presentations, radiological findings, approaches and incidence of residual tumor. Forty-seven patients with pituitary adenoma underwent trans-sphenoidal hypophysectomy of which 25 patients with complete medical and radiological data were included in the study. The medical and radiological data were analyzed. There were 12 males and 13 females with age ranging from 17 to 76 years old (mean 49.2). Fourteen of the patients were Chinese, eight Malays and three Indians. Twelve of the patients had functioning tumor of which five each presented with acromegaly and Cushing disease respectively and two with amenorrhoea. The rest of 13 patients had non functioning tumor presenting with visual disturbances. Sixteen of the patients had pituitary macro adenomas and the rest 9 microadenomas. Eighteen patients had undergone trans collumellar trans sphenoidal hypophysectomy and the rest 7 patients had undergone transnasal transsphenoidal hypophysectomy. About 68.8% of pituitary macro adenomas had residual tumor, compared to only 22.2% of patient with pituitary micro adenomas. Radiologically, about 45.5% of residual macroadenoma had suprasellar extension and the majority had spread to suprasellar cistern and carvenous sinus (54.5%). About 16.6% of patients had undergone post operative radiotherapy. In conclusion, this study showed that patient with pituitary macroadenomas had higher incidence of residual tumor compared to pituitary microadenomas.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalMedical Journal of Malaysia
Volume66
Issue number5
Publication statusPublished - Dec 2011

Fingerprint

Pituitary Neoplasms
Hypophysectomy
Residual Neoplasm
Pituitary ACTH Hypersecretion
Acromegaly
Amenorrhea
Incidence
Neoplasms
Radiotherapy
Demography

Keywords

  • Endonasal endoscopic
  • Hypophysectomy
  • Macroadenoma
  • Microadenoma
  • Pituitary adenoma
  • Residual tumour
  • Transcollumellar

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{b6ac7b33dee94fa390fbaf1f83eda8ee,
title = "Endonasal endoscopic transsphenoidal pituitary surgery for pituitary adenoma: A retrospective analysis of surgical outcome",
abstract = "The purpose of this retrospective joint rhino-neurosurgical study from January 1998 until September 2009 is to document the demographic data, clinical presentations, radiological findings, approaches and incidence of residual tumor. Forty-seven patients with pituitary adenoma underwent trans-sphenoidal hypophysectomy of which 25 patients with complete medical and radiological data were included in the study. The medical and radiological data were analyzed. There were 12 males and 13 females with age ranging from 17 to 76 years old (mean 49.2). Fourteen of the patients were Chinese, eight Malays and three Indians. Twelve of the patients had functioning tumor of which five each presented with acromegaly and Cushing disease respectively and two with amenorrhoea. The rest of 13 patients had non functioning tumor presenting with visual disturbances. Sixteen of the patients had pituitary macro adenomas and the rest 9 microadenomas. Eighteen patients had undergone trans collumellar trans sphenoidal hypophysectomy and the rest 7 patients had undergone transnasal transsphenoidal hypophysectomy. About 68.8{\%} of pituitary macro adenomas had residual tumor, compared to only 22.2{\%} of patient with pituitary micro adenomas. Radiologically, about 45.5{\%} of residual macroadenoma had suprasellar extension and the majority had spread to suprasellar cistern and carvenous sinus (54.5{\%}). About 16.6{\%} of patients had undergone post operative radiotherapy. In conclusion, this study showed that patient with pituitary macroadenomas had higher incidence of residual tumor compared to pituitary microadenomas.",
keywords = "Endonasal endoscopic, Hypophysectomy, Macroadenoma, Microadenoma, Pituitary adenoma, Residual tumour, Transcollumellar",
author = "Saad, {Mohd Sazafi Mohd} and Gendeh, {Balwant Singh} and Salina Husain",
year = "2011",
month = "12",
language = "English",
volume = "66",
pages = "443--446",
journal = "Medical Journal of Malaysia",
issn = "0300-5283",
publisher = "Malaysian Medical Association",
number = "5",

}

TY - JOUR

T1 - Endonasal endoscopic transsphenoidal pituitary surgery for pituitary adenoma

T2 - A retrospective analysis of surgical outcome

AU - Saad, Mohd Sazafi Mohd

AU - Gendeh, Balwant Singh

AU - Husain, Salina

PY - 2011/12

Y1 - 2011/12

N2 - The purpose of this retrospective joint rhino-neurosurgical study from January 1998 until September 2009 is to document the demographic data, clinical presentations, radiological findings, approaches and incidence of residual tumor. Forty-seven patients with pituitary adenoma underwent trans-sphenoidal hypophysectomy of which 25 patients with complete medical and radiological data were included in the study. The medical and radiological data were analyzed. There were 12 males and 13 females with age ranging from 17 to 76 years old (mean 49.2). Fourteen of the patients were Chinese, eight Malays and three Indians. Twelve of the patients had functioning tumor of which five each presented with acromegaly and Cushing disease respectively and two with amenorrhoea. The rest of 13 patients had non functioning tumor presenting with visual disturbances. Sixteen of the patients had pituitary macro adenomas and the rest 9 microadenomas. Eighteen patients had undergone trans collumellar trans sphenoidal hypophysectomy and the rest 7 patients had undergone transnasal transsphenoidal hypophysectomy. About 68.8% of pituitary macro adenomas had residual tumor, compared to only 22.2% of patient with pituitary micro adenomas. Radiologically, about 45.5% of residual macroadenoma had suprasellar extension and the majority had spread to suprasellar cistern and carvenous sinus (54.5%). About 16.6% of patients had undergone post operative radiotherapy. In conclusion, this study showed that patient with pituitary macroadenomas had higher incidence of residual tumor compared to pituitary microadenomas.

AB - The purpose of this retrospective joint rhino-neurosurgical study from January 1998 until September 2009 is to document the demographic data, clinical presentations, radiological findings, approaches and incidence of residual tumor. Forty-seven patients with pituitary adenoma underwent trans-sphenoidal hypophysectomy of which 25 patients with complete medical and radiological data were included in the study. The medical and radiological data were analyzed. There were 12 males and 13 females with age ranging from 17 to 76 years old (mean 49.2). Fourteen of the patients were Chinese, eight Malays and three Indians. Twelve of the patients had functioning tumor of which five each presented with acromegaly and Cushing disease respectively and two with amenorrhoea. The rest of 13 patients had non functioning tumor presenting with visual disturbances. Sixteen of the patients had pituitary macro adenomas and the rest 9 microadenomas. Eighteen patients had undergone trans collumellar trans sphenoidal hypophysectomy and the rest 7 patients had undergone transnasal transsphenoidal hypophysectomy. About 68.8% of pituitary macro adenomas had residual tumor, compared to only 22.2% of patient with pituitary micro adenomas. Radiologically, about 45.5% of residual macroadenoma had suprasellar extension and the majority had spread to suprasellar cistern and carvenous sinus (54.5%). About 16.6% of patients had undergone post operative radiotherapy. In conclusion, this study showed that patient with pituitary macroadenomas had higher incidence of residual tumor compared to pituitary microadenomas.

KW - Endonasal endoscopic

KW - Hypophysectomy

KW - Macroadenoma

KW - Microadenoma

KW - Pituitary adenoma

KW - Residual tumour

KW - Transcollumellar

UR - http://www.scopus.com/inward/record.url?scp=84857074803&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857074803&partnerID=8YFLogxK

M3 - Article

VL - 66

SP - 443

EP - 446

JO - Medical Journal of Malaysia

JF - Medical Journal of Malaysia

SN - 0300-5283

IS - 5

ER -