Emerging trends on drug delivery strategy of Momordica charantia against diabetes and its complications

Zar Chi Thent, Srijit Das, Nurul Hannim Zaidun

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background: The incidence of diabetes mellitus has increased drastically over the past few decades. This oxidant-antioxidant imbalance resulting in complication of diabetes mellitus includes macro- and microvascular complications. Resistance to conventional treatment and patient compliance has paved the way to the usage of effective natural products and supplements. Momordica charantia (bitter gourd) is widely consumed in many parts of Malaysia as a vegetable. Momordica charantia (MC) is mainly used in the management of diabetes mellitus. Objective: The present review discusses the literature concerning the antidiabetic and antioxidant properties of MC focusing on the complication of diabetes mellitus along with its mode of delivery. We found that among the whole part of MC, its fruit extract has been widely studied, therapeutically. The evidence based analysis of the beneficiary effects of MC on the different organs involved in diabetes complication is also highlighted. This review elucidated an essential understanding of MC based drug delivery system in both clinical and experimental studies and appraised the great potential of the protein based MC extract against diabetes mellitus. Conclusion: The review paper is believed to assist the researchers and medical personnel in treating diabetic associated complications.

Original languageEnglish
Pages (from-to)453-460
Number of pages8
JournalCurrent Drug Delivery
Volume15
Issue number4
DOIs
Publication statusPublished - 1 Jan 2018

Fingerprint

Momordica charantia
Diabetes Complications
Pharmaceutical Preparations
Diabetes Mellitus
Antioxidants
Malaysia
Drug Delivery Systems
Patient Compliance
Biological Products
Hypoglycemic Agents
Oxidants
Vegetables
Fruit
Research Personnel

Keywords

  • Antioxidant
  • Complications
  • Diabetes mellitus
  • Drug delivery
  • Momordica charantia
  • Oxidant

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Emerging trends on drug delivery strategy of Momordica charantia against diabetes and its complications. / Thent, Zar Chi; Das, Srijit; Zaidun, Nurul Hannim.

In: Current Drug Delivery, Vol. 15, No. 4, 01.01.2018, p. 453-460.

Research output: Contribution to journalReview article

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