Emerging trends in therapeutic algorithm of chronic wound healers

Recent advances in drug delivery systems, concepts-to-clinical application and future prospects

Mei Shao, Zahid Hussain, Hnin Ei Thu, Shahzeb Khan, Marcel de Matas, Victoria Silkstone, Hua Li Qin, Bukhari Syed Nasir Abbas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Chronic wounds which include diabetic foot ulcer (DFU), pressure ulcer, and arterial or venous ulcers compel a significant burden to the patients, healthcare providers, and the healthcare system. Chronic wounds are characterized by an excessive persistent inflammatory phase, prolonged infection, and the failure of defense cells to respond to environmental stimuli. Unlike acute wounds, chronic nonhealing wounds pose a substantial challenge to conventional wound dressings, and the development of novel and advanced wound healing modalities is needed. Toward this end, numerous conventional wound-healing modalities have been evaluated in the management of nonhealing wounds, but a multifaceted approach is lacking. Therefore, this review aims to compile and explore the wide therapeutic algorithm of current and advanced wound healing approaches to the treatment of chronic wounds. The algorithm of chronic wound healing techniques includes conventional wound dressings; approaches based on autografts, allografts, and cultured epithelial autografts; and recent modalities based on natural, modified or synthetic polymers and biomaterials, processed mutually in the form of hydrogels, films, hydrocolloids, and foams. Moreover, this review also explores the promising potential of advanced drug delivery systems for the sustained delivery of growth factors, curcumin, aloe vera, hyaluronic acid, and other bioactive substances as well as stem cell therapy. The current review summarizes the convincing evidence for the clinical dominance of polymer-based chronic wound healing modalities as well as the latest and innovative therapeutic strategies for the treatment of chronic wounds.

Original languageEnglish
Pages (from-to)387-452
Number of pages66
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume34
Issue number5
DOIs
Publication statusPublished - 1 Jan 2017
Externally publishedYes

Fingerprint

Drug Delivery Systems
Wounds and Injuries
Wound Healing
Therapeutics
Autografts
Bandages
Polymers
Aloe
Varicose Ulcer
Diabetic Foot
Curcumin
Pressure Ulcer
Colloids
Biocompatible Materials
Hyaluronic Acid
Cell- and Tissue-Based Therapy
Health Personnel
Allografts
Intercellular Signaling Peptides and Proteins
Stem Cells

Keywords

  • Advanced therapies
  • Chronic wounds
  • Conventional dressing
  • Efficacy upgradation
  • Natural and synthetic polymers
  • Nonlinear healing

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Emerging trends in therapeutic algorithm of chronic wound healers : Recent advances in drug delivery systems, concepts-to-clinical application and future prospects. / Shao, Mei; Hussain, Zahid; Thu, Hnin Ei; Khan, Shahzeb; de Matas, Marcel; Silkstone, Victoria; Qin, Hua Li; Syed Nasir Abbas, Bukhari.

In: Critical Reviews in Therapeutic Drug Carrier Systems, Vol. 34, No. 5, 01.01.2017, p. 387-452.

Research output: Contribution to journalArticle

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