Emerging anticancer potentials of selenium on osteosarcoma

Kok Lun Pang, Kok Yong Chin

Research output: Contribution to journalReview article

Abstract

Selenium is a trace element essential to humans and forms complexes with proteins, which exert physiological functions in the body. In vitro studies suggested that selenium possesses anticancer effects and may be effective against osteosarcoma. This review aims to summarise current evidence on the anticancer activity of inorganic and organic selenium on osteosarcoma. Cellular studies revealed that inorganic and organic selenium shows cytotoxicity, anti-proliferative and pro-apoptotic effects on various osteosarcoma cell lines. These actions may be mediated by oxidative stress induced by selenium compounds, leading to the activation of p53, proapoptotic proteins and caspases. Inorganic selenium is selective towards cancer cells, but can cause non-selective cell death at a high dose. This condition challenges the controlled release of selenium from biomaterials. Selenium treatment in animals inoculated with osteosarcoma reduced the tumour size, but did not eliminate the incidence of osteosarcoma. Only one study investigated the relationship between selenium and osteosarcoma in humans, but the results were inconclusive. In summary, although selenium may exert anticancer properties on osteosarcoma in experimental model systems, its effects in humans require further investigation.

Original languageEnglish
Article number5318
JournalInternational journal of molecular sciences
Volume20
Issue number21
DOIs
Publication statusPublished - 1 Nov 2019

Fingerprint

Selenium
Osteosarcoma
selenium
emerging
Selenium compounds
selenium compounds
Selenium Compounds
Cells
proteins
Proteins
Oxidative stress
Trace Elements
Biocompatible Materials
Cell death
Cytotoxicity
Caspases
Trace elements
cultured cells
trace elements
Biomaterials

Keywords

  • Bone
  • Cancer
  • Chemoprevention
  • Osteoblasts
  • Oxidative stress
  • Trace elements

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

Emerging anticancer potentials of selenium on osteosarcoma. / Pang, Kok Lun; Chin, Kok Yong.

In: International journal of molecular sciences, Vol. 20, No. 21, 5318, 01.11.2019.

Research output: Contribution to journalReview article

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