Emergence of MRSA in positive blood cultures from patients with febrile neutropenia - A cause for concern

Patrick G. Morris, Hassan Tidi Maharani, Mairead McNamara, Astrid Hassan, Rebecca Wiig, Liam Grogan, Oscar S. Breathnach, Edmond Smyth, Hilary Humphreys

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Goals of work: Febrile neutropenia (FN) causes considerable morbidity in patients on cytotoxic chemotherapy. Recently, there has been a trend towards fewer Gram-negative and more Gram-positive infections with increasing antibiotic resistance. To assess these patterns, data from a supra-regional cancer centre in Ireland were reviewed. Patients and methods: A 5-year review of all positive blood cultures in patients undergoing anti-cancer chemotherapy was carried out. Main results: Eight hundred and ninety-four patients were reviewed. The mean incidence of FN was 64.2 cases per year. Eight hundred and forty-six blood culture specimens were taken and 173 (20.4%) were culture positive. The isolated organisms were Gram positive (71.1%), Gram negative (27.8%) and fungal (1.1%). Of the Gram-positive organisms, 75.6% were staphylococci. Of these, 67.8% were coagulase-negative staphylococci and 30.1% were Staphylococci aureus. Amongst the S. aureus, 89.3% were methicillin-resistant (MRSA). Vancomycin-resistant enterococci were not identified as a cause of positive blood cultures. Conclusions: Amongst patients with cancer who develop FN in our hospital, Gram-positive bacteria account for the largest proportion. The high proportion of MRSA as a cause of positive blood cultures is of concern.

Original languageEnglish
Pages (from-to)1085-1088
Number of pages4
JournalSupportive Care in Cancer
Volume16
Issue number9
DOIs
Publication statusPublished - Sep 2008
Externally publishedYes

Fingerprint

Febrile Neutropenia
Methicillin Resistance
Staphylococcus
Staphylococcus aureus
Drug Therapy
Neoplasms
Coagulase
Gram-Positive Bacteria
Microbial Drug Resistance
Ireland
Blood Culture
Morbidity
Incidence
Infection

Keywords

  • Blood cultures
  • Febrile neutropenia
  • MRSA
  • VRE

ASJC Scopus subject areas

  • Oncology
  • Nursing(all)

Cite this

Morris, P. G., Tidi Maharani, H., McNamara, M., Hassan, A., Wiig, R., Grogan, L., ... Humphreys, H. (2008). Emergence of MRSA in positive blood cultures from patients with febrile neutropenia - A cause for concern. Supportive Care in Cancer, 16(9), 1085-1088. https://doi.org/10.1007/s00520-007-0398-5

Emergence of MRSA in positive blood cultures from patients with febrile neutropenia - A cause for concern. / Morris, Patrick G.; Tidi Maharani, Hassan; McNamara, Mairead; Hassan, Astrid; Wiig, Rebecca; Grogan, Liam; Breathnach, Oscar S.; Smyth, Edmond; Humphreys, Hilary.

In: Supportive Care in Cancer, Vol. 16, No. 9, 09.2008, p. 1085-1088.

Research output: Contribution to journalArticle

Morris, PG, Tidi Maharani, H, McNamara, M, Hassan, A, Wiig, R, Grogan, L, Breathnach, OS, Smyth, E & Humphreys, H 2008, 'Emergence of MRSA in positive blood cultures from patients with febrile neutropenia - A cause for concern', Supportive Care in Cancer, vol. 16, no. 9, pp. 1085-1088. https://doi.org/10.1007/s00520-007-0398-5
Morris, Patrick G. ; Tidi Maharani, Hassan ; McNamara, Mairead ; Hassan, Astrid ; Wiig, Rebecca ; Grogan, Liam ; Breathnach, Oscar S. ; Smyth, Edmond ; Humphreys, Hilary. / Emergence of MRSA in positive blood cultures from patients with febrile neutropenia - A cause for concern. In: Supportive Care in Cancer. 2008 ; Vol. 16, No. 9. pp. 1085-1088.
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