Abstract
Background: In 1998, Malaysia experienced its first chikungunya virus (CHIKV) outbreak in the suburban areas followed by another two in 2006 (rural areas) and 2008 (urban areas), respectively. Nevertheless, there is still a lack of documented data regarding the magnitude of CHIKV exposure in the Malaysian population. The aim of this study was to determine the extent of chikungunya virus infection in healthy Malaysian adults residing in outbreak-free locations.Methods: A cross sectional study of chikungunya (CHIK) seroprevalence was carried out in 2009 amongst The Malaysian Cohort participants living in four states (Kuala Lumpur, Selangor, Pahang and Negeri Sembilan). A total of 945 participants were randomly identified for the study. Potential risk factors for CHIK infection were determined via questionnaires, and IgG antibodies against CHIK were detected by an enzyme-linked immunosorbent assay. Logistic regression identified risk factors associated with CHIK seropositivity, while geographical information system was used for visual and spatial analysis.Results: From the 945 serum samples tested, 5.9% was positive for CHIK IgG. Being male, Malay, rural occupancy and Negeri Sembilan residency were identified as univariate predictors for CHIK seropositivity, while multivariate analysis identified being male and rural occupancy as risk factors.Conclusions: This study provided evidence that CHIK is slowly emerging in Malaysia. Although the current baseline seroprevalence is low in this country, increasing number of CHIK cases reported to the Malaysia Ministry of Health imply the possibility of CHIK virus becoming endemic in Malaysia.
| Original language | English |
|---|---|
| Article number | 67 |
| Journal | BMC Infectious Diseases |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 9 Feb 2013 |
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Keywords
- Adult
- Chikungunya virus
- Malaysia/Epidemiology
- Rural
- Seroprevalence study
ASJC Scopus subject areas
- Infectious Diseases
Cite this
Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations : Chikungunya seroprevalence results from the Malaysian Cohort. / Azami, Nor Azila Muhammad; Salleh, Sharifah Azura; Shah, Shamsul Azhar; Neoh, Hui Min; Othman, Zulhabri; Syed Zakaria, Syed Zulkifli; A. Jamal, A. Rahman.
In: BMC Infectious Diseases, Vol. 13, No. 1, 67, 09.02.2013.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Emergence of chikungunya seropositivity in healthy Malaysian adults residing in outbreak-free locations
T2 - Chikungunya seroprevalence results from the Malaysian Cohort
AU - Azami, Nor Azila Muhammad
AU - Salleh, Sharifah Azura
AU - Shah, Shamsul Azhar
AU - Neoh, Hui Min
AU - Othman, Zulhabri
AU - Syed Zakaria, Syed Zulkifli
AU - A. Jamal, A. Rahman
PY - 2013/2/9
Y1 - 2013/2/9
N2 - Background: In 1998, Malaysia experienced its first chikungunya virus (CHIKV) outbreak in the suburban areas followed by another two in 2006 (rural areas) and 2008 (urban areas), respectively. Nevertheless, there is still a lack of documented data regarding the magnitude of CHIKV exposure in the Malaysian population. The aim of this study was to determine the extent of chikungunya virus infection in healthy Malaysian adults residing in outbreak-free locations.Methods: A cross sectional study of chikungunya (CHIK) seroprevalence was carried out in 2009 amongst The Malaysian Cohort participants living in four states (Kuala Lumpur, Selangor, Pahang and Negeri Sembilan). A total of 945 participants were randomly identified for the study. Potential risk factors for CHIK infection were determined via questionnaires, and IgG antibodies against CHIK were detected by an enzyme-linked immunosorbent assay. Logistic regression identified risk factors associated with CHIK seropositivity, while geographical information system was used for visual and spatial analysis.Results: From the 945 serum samples tested, 5.9% was positive for CHIK IgG. Being male, Malay, rural occupancy and Negeri Sembilan residency were identified as univariate predictors for CHIK seropositivity, while multivariate analysis identified being male and rural occupancy as risk factors.Conclusions: This study provided evidence that CHIK is slowly emerging in Malaysia. Although the current baseline seroprevalence is low in this country, increasing number of CHIK cases reported to the Malaysia Ministry of Health imply the possibility of CHIK virus becoming endemic in Malaysia.
AB - Background: In 1998, Malaysia experienced its first chikungunya virus (CHIKV) outbreak in the suburban areas followed by another two in 2006 (rural areas) and 2008 (urban areas), respectively. Nevertheless, there is still a lack of documented data regarding the magnitude of CHIKV exposure in the Malaysian population. The aim of this study was to determine the extent of chikungunya virus infection in healthy Malaysian adults residing in outbreak-free locations.Methods: A cross sectional study of chikungunya (CHIK) seroprevalence was carried out in 2009 amongst The Malaysian Cohort participants living in four states (Kuala Lumpur, Selangor, Pahang and Negeri Sembilan). A total of 945 participants were randomly identified for the study. Potential risk factors for CHIK infection were determined via questionnaires, and IgG antibodies against CHIK were detected by an enzyme-linked immunosorbent assay. Logistic regression identified risk factors associated with CHIK seropositivity, while geographical information system was used for visual and spatial analysis.Results: From the 945 serum samples tested, 5.9% was positive for CHIK IgG. Being male, Malay, rural occupancy and Negeri Sembilan residency were identified as univariate predictors for CHIK seropositivity, while multivariate analysis identified being male and rural occupancy as risk factors.Conclusions: This study provided evidence that CHIK is slowly emerging in Malaysia. Although the current baseline seroprevalence is low in this country, increasing number of CHIK cases reported to the Malaysia Ministry of Health imply the possibility of CHIK virus becoming endemic in Malaysia.
KW - Adult
KW - Chikungunya virus
KW - Malaysia/Epidemiology
KW - Rural
KW - Seroprevalence study
UR - http://www.scopus.com/inward/record.url?scp=84873267594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84873267594&partnerID=8YFLogxK
U2 - 10.1186/1471-2334-13-67
DO - 10.1186/1471-2334-13-67
M3 - Article
C2 - 23379541
AN - SCOPUS:84873267594
VL - 13
JO - BMC Infectious Diseases
JF - BMC Infectious Diseases
SN - 1471-2334
IS - 1
M1 - 67
ER -