Elemental analysis of herbal preparations for traditional medicines by neutron activation analysis with the k0 standardization method

Sukiman Sarmani, I. Abügassa, A. Hamzah, M. D. Yahya

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Medicinal herb preparations prescribed for specific treatment purposes were purchased from markets and were analyzed by instrumental neutron activation analysis with k0 standardization. Then, 500-700 mg of each sample was pelletized under a pressure of six tones and irradiated together with monitors for α and neutron flux ratio determinations for about 6 h in a thermal flux of 2.29 x 1012 n/cm2/s. The accuracy of the method was established by analyzing standard reference materials. Twenty-nine elements, Ag, As, Au, Ba, Br, Ca, Ce, Co, Cr, Cs, Eu, Fe, Hf, K, La, Mn, Mo, Na, Rb, Sb, Sc, Se, Sm, Sr, Th, U, Yb, and Zn, were measured in all the samples, and Hg was detected in some samples, with good accuracy and reproducibility. The concentration of elements determined was found to vary depending on the composition of the herbs used. Although the trend linking the element of the medicinal plants to its curative abilities could not be clearly determined, this study showed that the toxic elements found in the samples were below the levels prescribed by health regulations. Nevertheless, such data are important to understand the pharmacological action and the exact mechanisms of action and formation of active constituents for each medicinal plant and to decide the dosage of the herbs used in the final formulation.

Original languageEnglish
Pages (from-to)365-376
Number of pages12
JournalBiological Trace Element Research
Volume71-72
Publication statusPublished - 1999
Externally publishedYes

Fingerprint

Plant Preparations
Neutron Activation Analysis
Neutron activation analysis
Neutron flux
Poisons
Traditional Medicine
Medicinal Plants
Standardization
Medicine
Health
Fluxes
Molecular Mechanisms of Pharmacological Action
Chemical analysis
Neutrons
Health Status
Hot Temperature
Pressure
Therapeutics

Keywords

  • Herbs
  • INAA
  • K standardization
  • Traditional medicines

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Elemental analysis of herbal preparations for traditional medicines by neutron activation analysis with the k0 standardization method. / Sarmani, Sukiman; Abügassa, I.; Hamzah, A.; Yahya, M. D.

In: Biological Trace Element Research, Vol. 71-72, 1999, p. 365-376.

Research output: Contribution to journalArticle

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