Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering

Jia Xian Law, Ling Ling Liau, Aminuddin Saim, Ying Yang, Ruszymah Idrus

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Electrospinning is a simple and versatile technique to fabricate continuous fibers with diameter ranging from micrometers to a few nanometers. To date, the number of polymers that have been electrospun has exceeded 200. In recent years, electrospinning has become one of the most popular scaffold fabrication techniques to prepare nanofiber mesh for tissue engineering applications. Collagen, the most abundant extracellular matrix protein in the human body, has been electrospun to fabricate biomimetic scaffolds that imitate the architecture of native human tissues. As collagen nanofibers are mechanically weak in nature, it is commonly cross-linked or blended with synthetic polymers to improve the mechanical strength without compromising the biological activity. Electrospun collagen nanofiber mesh has high surface area to volume ratio, tunable diameter and porosity, and excellent biological activity to regulate cell function and tissue formation. Due to these advantages, collagen nanofibers have been tested for the regeneration of a myriad of tissues and organs. In this review, we gave an overview of electrospinning, encompassing the history, the instrument settings, the spinning process and the parameters that affect fiber formation, with emphasis given to collagen nanofibers’ fabrication and application, especially the use of collagen nanofibers in skin tissue engineering.

Original languageEnglish
Pages (from-to)699-718
Number of pages20
JournalTissue Engineering and Regenerative Medicine
Volume14
Issue number6
DOIs
Publication statusPublished - 1 Dec 2017

Fingerprint

Nanofibers
Tissue Engineering
Tissue engineering
Collagen
Skin
Electrospinning
Scaffolds (biology)
Tissue
Bioactivity
Polymers
Fabrication
Biomimetics
Fibers
Extracellular Matrix Proteins
Porosity
Human Body
Population Groups
Strength of materials
Regeneration
History

Keywords

  • Collagen
  • Electrospinning
  • Nanofiber
  • Scaffold
  • Skin
  • Tissue engineering

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering. / Law, Jia Xian; Liau, Ling Ling; Saim, Aminuddin; Yang, Ying; Idrus, Ruszymah.

In: Tissue Engineering and Regenerative Medicine, Vol. 14, No. 6, 01.12.2017, p. 699-718.

Research output: Contribution to journalReview article

Law, Jia Xian ; Liau, Ling Ling ; Saim, Aminuddin ; Yang, Ying ; Idrus, Ruszymah. / Electrospun Collagen Nanofibers and Their Applications in Skin Tissue Engineering. In: Tissue Engineering and Regenerative Medicine. 2017 ; Vol. 14, No. 6. pp. 699-718.
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