Electrochemical Studies of Cu(phen)edda Interaction with DNA

C. W. Yaw, W. T. Tan, W. S. Tan, C. H. Ng, Wei Boon Yap, N. H. Rahman, Mohamed Zidan

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Copper phenanthroline ethylenediaminediacetic acid, [Cu(phen)(edda)]·5H 2O, has been synthesized and characterized using cyclic voltammetry (CV), chronocoulometry (CC), chronoamperometry (CA), and rotating disk electrode (RDE). The copper(II) complex is found to be electroactive as shown by its well defined redox waveforms during cyclic voltammetry at room temperature and at pH 6.8. The interaction between [Cu(phen)(edda)]·5H 2O and DNA was also investigated using cyclic voltammetry at room temperature and at pH 6.8. The above electrochemical interaction was evident as their CV results revealing a slight shift in formal potential (at a range of 5 to 23mV dependant on scan rat, and a significant changes in redox peak currents (at a range of 0.05 to 0.4 times dependant on scan rate) to that of Cu(II) complexes in the presence of DNA. Copper (II) complex dissociates more easily as solution acidity increases as is evident by its larger current and decreases in peaks separation. Based on hydrodynamic voltammetric studies, the diffusion coefficients copper complex is found to be of the order of 10-7cm2/s and kinetic rate constant of 10 -5cm/s.

Original languageEnglish
Pages (from-to)4692-4701
Number of pages10
JournalInternational Journal of Electrochemical Science
Volume7
Issue number5
Publication statusPublished - 2012
Externally publishedYes

Fingerprint

Phenanthrolines
Cyclic voltammetry
DNA
Copper
Acids
Chronoamperometry
Rotating disks
Acidity
Rats
Rate constants
Hydrodynamics
Temperature
Electrodes
Kinetics
Oxidation-Reduction

Keywords

  • [Cu(phen)(edda)]·5H O
  • DNA
  • Interaction
  • Voltammetry

ASJC Scopus subject areas

  • Electrochemistry

Cite this

Yaw, C. W., Tan, W. T., Tan, W. S., Ng, C. H., Yap, W. B., Rahman, N. H., & Zidan, M. (2012). Electrochemical Studies of Cu(phen)edda Interaction with DNA. International Journal of Electrochemical Science, 7(5), 4692-4701.

Electrochemical Studies of Cu(phen)edda Interaction with DNA. / Yaw, C. W.; Tan, W. T.; Tan, W. S.; Ng, C. H.; Yap, Wei Boon; Rahman, N. H.; Zidan, Mohamed.

In: International Journal of Electrochemical Science, Vol. 7, No. 5, 2012, p. 4692-4701.

Research output: Contribution to journalArticle

Yaw, CW, Tan, WT, Tan, WS, Ng, CH, Yap, WB, Rahman, NH & Zidan, M 2012, 'Electrochemical Studies of Cu(phen)edda Interaction with DNA', International Journal of Electrochemical Science, vol. 7, no. 5, pp. 4692-4701.
Yaw, C. W. ; Tan, W. T. ; Tan, W. S. ; Ng, C. H. ; Yap, Wei Boon ; Rahman, N. H. ; Zidan, Mohamed. / Electrochemical Studies of Cu(phen)edda Interaction with DNA. In: International Journal of Electrochemical Science. 2012 ; Vol. 7, No. 5. pp. 4692-4701.
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