Efficacy of oral clonidine as pre-anesthetic medication in reduction of post-operative pain in children- a randomized controlled trial

Asadul Mazid Helali, Zaida Rahman, Rukhsana Amin, Rabeya Yousuf, Arefuddin Ahmed, Abdus Salam, Mainul Haque

Research output: Contribution to journalArticle

Abstract

Clonidine is α2 agonist antihypertensive drug but its use is limited because of multiple adverse effects including sedation. Clonidine also has effective pre-anesthetic and analgesic-properties that have been well documented in adults in different parts of the world. This drug has substantially decrease opioid or volatile anaesthetics requirements with definite improvement of cardiovascular markers. The current study was designed to investigate the efficacy of oral clonidine as pre-anaesthetic medication in reduction of post-operative pain among Bangladeshi children. This randomized, controlled trial was performed in year 2010-2011 in a private medical college in Bangladesh. A total of 60 children aged 3 months-3 years undergoing minor surgery received placebo (control) and clonidine 4μg/kg, 100 min before induction of anesthesia and followed by oral atropine 0.03 mg/kg, 60 minutes before anesthesia. Anaesthesia was induced and maintained with halothane and nitrous oxide with oxygen. Post-operative pain was assessed using objective pain scale (OPS). Clonidine provided lower OPS scores and reduced requirement for postoperative supplementary analgesic compared to the control. These data suggest that oral clonidine is a possible approach to facilitate post-operative analgesia in children undergoing minor surgery.

Original languageEnglish
Pages (from-to)632-636
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume6
Issue number6
Publication statusPublished - 2013

Fingerprint

Clonidine
Anesthetics
Randomized Controlled Trials
Pain
Minor Surgical Procedures
Anesthesia
Analgesics
Bangladesh
Nitrous Oxide
Halothane
Atropine
Analgesia
Opioid Analgesics
Antihypertensive Agents
Placebos
Oxygen
Pharmaceutical Preparations

Keywords

  • Clonidine
  • Pain Reduction
  • Post-operative
  • Pre-anaesthetic Medication

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

Cite this

Efficacy of oral clonidine as pre-anesthetic medication in reduction of post-operative pain in children- a randomized controlled trial. / Helali, Asadul Mazid; Rahman, Zaida; Amin, Rukhsana; Yousuf, Rabeya; Ahmed, Arefuddin; Salam, Abdus; Haque, Mainul.

In: Research Journal of Pharmacy and Technology, Vol. 6, No. 6, 2013, p. 632-636.

Research output: Contribution to journalArticle

Helali, Asadul Mazid ; Rahman, Zaida ; Amin, Rukhsana ; Yousuf, Rabeya ; Ahmed, Arefuddin ; Salam, Abdus ; Haque, Mainul. / Efficacy of oral clonidine as pre-anesthetic medication in reduction of post-operative pain in children- a randomized controlled trial. In: Research Journal of Pharmacy and Technology. 2013 ; Vol. 6, No. 6. pp. 632-636.
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