Efficacy of L-carnitine supplementation on frailty status and its biomarkers,nutritional status,and physical and cognitive function among prefrail older adults: A double-blind,randomized,placebo-controlled clinical trial

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency,including L-carnitine,has been proposed to be associated with its pathophysiology. Nevertheless,the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus,this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function,cognition,and nutritional status among prefrail older adults in Klang Valley,Malaysia. Methodology: This study is a randomized,double-blind,placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit,selected frailty biomarkers (interleukin-6,tumor necrosis factor-alpha,and insulin-like growth factor-1),physical function,cognitive function,nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria,four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults.

Original languageEnglish
Pages (from-to)1675-1686
Number of pages12
JournalClinical Interventions in Aging
Volume11
DOIs
Publication statusPublished - 17 Nov 2016

Fingerprint

Carnitine
Nutritional Status
Cognition
Randomized Controlled Trials
Biomarkers
Placebos
Malaysia
Controlled Clinical Trials
Hand Strength
Somatomedins
Fatigue
Interleukin-6
Hand
Tumor Necrosis Factor-alpha
Outcome Assessment (Health Care)
Amino Acids
Control Groups

Keywords

  • Frailty
  • Frailty biomarkers
  • Frailty Index accumulation of deficit
  • Fried criteria
  • L-carnitine supplementation
  • Physical function
  • Prefrail elderly
  • Randomized controlled clinical trial

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

@article{7327ec6c4d204c189df344e1278c8352,
title = "Efficacy of L-carnitine supplementation on frailty status and its biomarkers,nutritional status,and physical and cognitive function among prefrail older adults: A double-blind,randomized,placebo-controlled clinical trial",
abstract = "Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency,including L-carnitine,has been proposed to be associated with its pathophysiology. Nevertheless,the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus,this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function,cognition,and nutritional status among prefrail older adults in Klang Valley,Malaysia. Methodology: This study is a randomized,double-blind,placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit,selected frailty biomarkers (interleukin-6,tumor necrosis factor-alpha,and insulin-like growth factor-1),physical function,cognitive function,nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria,four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults.",
keywords = "Frailty, Frailty biomarkers, Frailty Index accumulation of deficit, Fried criteria, L-carnitine supplementation, Physical function, Prefrail elderly, Randomized controlled clinical trial",
author = "M. Badrasawi and Suzana Shahar and {Abdul Manaf}, Zahara and Rajab, {Nor Fadilah} and {Ajit Singh}, {Devinder Kaur}",
year = "2016",
month = "11",
day = "17",
doi = "10.2147/CIA.S113287",
language = "English",
volume = "11",
pages = "1675--1686",
journal = "Clinical Interventions in Aging",
issn = "1176-9092",
publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Efficacy of L-carnitine supplementation on frailty status and its biomarkers,nutritional status,and physical and cognitive function among prefrail older adults

T2 - A double-blind,randomized,placebo-controlled clinical trial

AU - Badrasawi, M.

AU - Shahar, Suzana

AU - Abdul Manaf, Zahara

AU - Rajab, Nor Fadilah

AU - Ajit Singh, Devinder Kaur

PY - 2016/11/17

Y1 - 2016/11/17

N2 - Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency,including L-carnitine,has been proposed to be associated with its pathophysiology. Nevertheless,the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus,this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function,cognition,and nutritional status among prefrail older adults in Klang Valley,Malaysia. Methodology: This study is a randomized,double-blind,placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit,selected frailty biomarkers (interleukin-6,tumor necrosis factor-alpha,and insulin-like growth factor-1),physical function,cognitive function,nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria,four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults.

AB - Background: Frailty is a biological syndrome of decreased reserve and resistance to stressors due to decline in multiple physiological systems. Amino acid deficiency,including L-carnitine,has been proposed to be associated with its pathophysiology. Nevertheless,the efficacy of L-carnitine supplementation on frailty status has not been documented. Thus,this study aimed to determine the effect of 10-week L-carnitine supplement (1.5 g/day) on frailty status and its biomarkers and also physical function,cognition,and nutritional status among prefrail older adults in Klang Valley,Malaysia. Methodology: This study is a randomized,double-blind,placebo-controlled clinical trial conducted among 50 prefrail subjects randomized into two groups (26 in L-carnitine group and 24 in placebo group). Outcome measures include frailty status using Fried criteria and Frailty Index accumulation of deficit,selected frailty biomarkers (interleukin-6,tumor necrosis factor-alpha,and insulin-like growth factor-1),physical function,cognitive function,nutritional status and biochemical profile. Results: The results indicated that the mean scores of Frailty Index score and hand grip test were significantly improved in subjects supplemented with L-carnitine (P0.05 for both parameters) as compared to no change in the placebo group. Based on Fried criteria,four subjects (three from the L-carnitine group and one from the control group) transited from prefrail status to robust after the intervention. Conclusion: L-carnitine supplementation has a favorable effect on the functional status and fatigue in prefrail older adults.

KW - Frailty

KW - Frailty biomarkers

KW - Frailty Index accumulation of deficit

KW - Fried criteria

KW - L-carnitine supplementation

KW - Physical function

KW - Prefrail elderly

KW - Randomized controlled clinical trial

UR - http://www.scopus.com/inward/record.url?scp=84996564027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84996564027&partnerID=8YFLogxK

U2 - 10.2147/CIA.S113287

DO - 10.2147/CIA.S113287

M3 - Article

C2 - 27895474

AN - SCOPUS:84996564027

VL - 11

SP - 1675

EP - 1686

JO - Clinical Interventions in Aging

JF - Clinical Interventions in Aging

SN - 1176-9092

ER -