Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet

Chow Chin Tong, Yew Keong Choong, S. Mohamed, Noordin M. Mohamed, Nor Aini Umar Aini

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Abstract

    Purpose - The purpose of this paper is to report on the anti-cholesterol activities of Ganoderma lucidum on Sprague-Dawley white rats. Design/methodology/approach - Rats were divided into four groups with a sample size of six rats per groups. Different formula diets were given to each group for a period of six months. At regular intervals, blood samples were taken and analysed for the total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein (LDL-C) levels. Findings - Administration of hyperlipidemia diet in rats fed with 1 per cent cholesterol diet caused an increase in the TC, TG, as well as LDL-C level as compared to the control. A decrease of 23.6 per cent in the HDL-C level was also noted. However, supplementation of the feed with G. lucidum (0.1 per cent) in rats decreased the TC, TG and LDL-C level significantly (P < 0.05) while further increased the plasma concentration of HDL-C. In the case of rats fed with diet containing a mixture of 1 per cent cholesterol and 0.1 per cent of Ganoderma, the lipid profile showed much higher readings (p < 0.05) compared to the chol group. Practical implications - The possible efficacy of G. lucidum in reducing the deposition of cholesterol in the wall of the blood vessels was indicated. Originality/value - This article provides useful information to health care providers and consumers.

    Original languageEnglish
    Pages (from-to)229-238
    Number of pages10
    JournalNutrition and Food Science
    Volume38
    Issue number3
    DOIs
    Publication statusPublished - 2008

    Fingerprint

    Reishi
    Ganoderma lucidum
    high fat diet
    lipoproteins
    blood lipids
    Lipoproteins
    Cholesterol
    cholesterol
    Diet
    Lipids
    rats
    triacylglycerols
    HDL Cholesterol
    high density lipoprotein cholesterol
    diet
    Triglycerides
    Ganoderma
    Formulated Food
    Hyperlipidemias
    LDL Lipoproteins

    Keywords

    • Alternative medicines
    • Diet
    • Malaysia

    ASJC Scopus subject areas

    • Food Science
    • Nutrition and Dietetics

    Cite this

    Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet. / Tong, Chow Chin; Choong, Yew Keong; Mohamed, S.; Mohamed, Noordin M.; Aini, Nor Aini Umar.

    In: Nutrition and Food Science, Vol. 38, No. 3, 2008, p. 229-238.

    Research output: Contribution to journalArticle

    Tong, Chow Chin ; Choong, Yew Keong ; Mohamed, S. ; Mohamed, Noordin M. ; Aini, Nor Aini Umar. / Efficacy of Ganoderma lucidum on plasma lipids and lipoproteins in rats fed with high cholesterol diet. In: Nutrition and Food Science. 2008 ; Vol. 38, No. 3. pp. 229-238.
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