Efficacy of ascorbic acid (Vitamin C) and/N-acetylcysteine (NAC) supplementation on nutritional and antioxidant status of male chronic obstructive pulmonary disease (COPD) patients

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7 Citations (Scopus)

Abstract

Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients. This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centers in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC_vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90% and significance level of p

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalJournal of Nutritional Science and Vitaminology
Volume62
Issue number1
DOIs
Publication statusPublished - 27 Apr 2016

Fingerprint

Acetylcysteine
Nutritional Status
Chronic Obstructive Pulmonary Disease
Ascorbic Acid
Antioxidants
Malaysia
Body Mass Index
Randomized Controlled Trials
Control Groups
Therapeutics

Keywords

  • Antioxidants
  • Chronic obstructive pulmonary disease
  • Dietary supplements
  • Malnutrition
  • Nutritional support

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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abstract = "Antioxidant therapy has a potential to be introduced as therapeutic modality for chronic obstructive pulmonary disease (COPD) patients. This study aimed to determine the effect of antioxidant supplementation [ascorbic acid and N-Acetylcysteine (NAC)] on nutritional and antioxidant status in male COPD patients. A parallel and single blind randomised controlled clinical trial (RCT) was conducted at two medical centers in Kuala Lumpur, Malaysia. Seventy-nine subjects were recruited and randomly divided into four trial arms (i.e., NAC, vitamin C, NAC_vitamin C and control groups) for six mo. The primary outcome was changes in body mass index by estimating power of 90{\%} and significance level of p",
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AU - Rajab, Nor Fadilah

AU - Abd. Manap, Roslina

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