Effects of vitamin E deficiency on bone metabolism in intact and ovariectomised growing female rats

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Abstract

The effects of long-term vitamin E deficiency on bone metabolism were studied in 4-month-old female Sprague-Dawley rats. Half of the rats were ovariectomised and the rest were left intact. The rats were divided into 3 groups and were fed with normal rat chow (control group), 50% vitamin E deficient diet or vitamin E deficient diet for nine months. Vitamin E deficiency significantly impaired calcification of both femoral and lumbar vertebral bones for both ovariectomised and intact rats. Bone mineral density was decreased in the femoral subregions of intact rats only. No decrease was seen in the lumbar vertebra of the vitamin E deficient intact rats. Bone mineral density was maintained at intact control levels for the vitamin E deficient ovariectomised rats. Serum alkaline phosphatase activities were increased in the vitamin E deficient diet groups for both the intact and ovariectomised rats. In conclusion, optimum vitamin E levels are needed to maintain bone calcification and bone mineral density. However, in ovariectomised rats, vitamin E could impair bone mineralization. This suggests that vitamin E may play different roles in bone metabolism in the presence and absence of estrogen and this observation needed further study. The requirements for vitamin E may also differ between the trabecular bones of the femur and lumbar vertebra.

Original languageEnglish
Pages (from-to)37-46
Number of pages10
JournalAsia Pacific Journal of Pharmacology
Volume15
Issue number3
Publication statusPublished - 2001

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Vitamin E Deficiency
Vitamin E
Bone and Bones
Bone Density
Lumbar Vertebrae
Diet
Thigh
Physiologic Calcification
Femur
Alkaline Phosphatase
Sprague Dawley Rats
Estrogens

Keywords

  • Bone metabolism
  • Female rats
  • Ovariectomy
  • Vitamin E deficiency

ASJC Scopus subject areas

  • Pharmacology

Cite this

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abstract = "The effects of long-term vitamin E deficiency on bone metabolism were studied in 4-month-old female Sprague-Dawley rats. Half of the rats were ovariectomised and the rest were left intact. The rats were divided into 3 groups and were fed with normal rat chow (control group), 50{\%} vitamin E deficient diet or vitamin E deficient diet for nine months. Vitamin E deficiency significantly impaired calcification of both femoral and lumbar vertebral bones for both ovariectomised and intact rats. Bone mineral density was decreased in the femoral subregions of intact rats only. No decrease was seen in the lumbar vertebra of the vitamin E deficient intact rats. Bone mineral density was maintained at intact control levels for the vitamin E deficient ovariectomised rats. Serum alkaline phosphatase activities were increased in the vitamin E deficient diet groups for both the intact and ovariectomised rats. In conclusion, optimum vitamin E levels are needed to maintain bone calcification and bone mineral density. However, in ovariectomised rats, vitamin E could impair bone mineralization. This suggests that vitamin E may play different roles in bone metabolism in the presence and absence of estrogen and this observation needed further study. The requirements for vitamin E may also differ between the trabecular bones of the femur and lumbar vertebra.",
keywords = "Bone metabolism, Female rats, Ovariectomy, Vitamin E deficiency",
author = "Norazlina Mohamed and Soelaiman, {Ima Nirwana} and Khalid, {B. A K}",
year = "2001",
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AU - Mohamed, Norazlina

AU - Soelaiman, Ima Nirwana

AU - Khalid, B. A K

PY - 2001

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N2 - The effects of long-term vitamin E deficiency on bone metabolism were studied in 4-month-old female Sprague-Dawley rats. Half of the rats were ovariectomised and the rest were left intact. The rats were divided into 3 groups and were fed with normal rat chow (control group), 50% vitamin E deficient diet or vitamin E deficient diet for nine months. Vitamin E deficiency significantly impaired calcification of both femoral and lumbar vertebral bones for both ovariectomised and intact rats. Bone mineral density was decreased in the femoral subregions of intact rats only. No decrease was seen in the lumbar vertebra of the vitamin E deficient intact rats. Bone mineral density was maintained at intact control levels for the vitamin E deficient ovariectomised rats. Serum alkaline phosphatase activities were increased in the vitamin E deficient diet groups for both the intact and ovariectomised rats. In conclusion, optimum vitamin E levels are needed to maintain bone calcification and bone mineral density. However, in ovariectomised rats, vitamin E could impair bone mineralization. This suggests that vitamin E may play different roles in bone metabolism in the presence and absence of estrogen and this observation needed further study. The requirements for vitamin E may also differ between the trabecular bones of the femur and lumbar vertebra.

AB - The effects of long-term vitamin E deficiency on bone metabolism were studied in 4-month-old female Sprague-Dawley rats. Half of the rats were ovariectomised and the rest were left intact. The rats were divided into 3 groups and were fed with normal rat chow (control group), 50% vitamin E deficient diet or vitamin E deficient diet for nine months. Vitamin E deficiency significantly impaired calcification of both femoral and lumbar vertebral bones for both ovariectomised and intact rats. Bone mineral density was decreased in the femoral subregions of intact rats only. No decrease was seen in the lumbar vertebra of the vitamin E deficient intact rats. Bone mineral density was maintained at intact control levels for the vitamin E deficient ovariectomised rats. Serum alkaline phosphatase activities were increased in the vitamin E deficient diet groups for both the intact and ovariectomised rats. In conclusion, optimum vitamin E levels are needed to maintain bone calcification and bone mineral density. However, in ovariectomised rats, vitamin E could impair bone mineralization. This suggests that vitamin E may play different roles in bone metabolism in the presence and absence of estrogen and this observation needed further study. The requirements for vitamin E may also differ between the trabecular bones of the femur and lumbar vertebra.

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KW - Ovariectomy

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