Effects of Tocopherols and Tocotrienols on Body Composition and Bone Calcium Content in Adrenalectomized Rats Replaced with Dexamethasone

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Long-term glucocorticoid treatment is associated with severe side effects, such as obesity and osteoporosis. A palm oil-derived vitamin E mixture had been shown previously to be protective against osteoporosis in rats given 120 μg/kg dexamethasone daily for 12 weeks. In this study we determined the effects of two isomers of vitamin E (i.e., palm oil-derived γ-tocotrienol and the commercially available α-tocopherol, 60 mg/kg of body weight/day) on body composition and bone calcium content in adrenalectomized rats replaced with two doses of dexamethasone, 120 μg/kg and 240 μg/kg daily. Treatment period was 8 weeks. γ-Tocotrienol (60 mg/kg of body weight/day) was found to reduce body fat mass and increase the fourth lumbar vertebra bone calcium content in these rats, while α-tocopherol (60 mg/kg of body weight/day) was ineffective. Therefore, in conclusion, palm oil-derived γ-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of the side effects of long-term glucocorticoid use.

Original languageEnglish
Pages (from-to)45-51
Number of pages7
JournalJournal of Medicinal Food
Volume7
Issue number1
DOIs
Publication statusPublished - Mar 2004

Fingerprint

Tocotrienols
tocotrienols
Tocopherols
palm oils
dexamethasone
Body Composition
tocopherols
Dexamethasone
body composition
osteoporosis
Body Weight
bones
glucocorticoids
Calcium
Vitamin E
calcium
Bone and Bones
Glucocorticoids
Osteoporosis
body weight

Keywords

  • α-tocopherol
  • γ-tocotrienol
  • Dexamethasone
  • Osteoporosis
  • Rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

@article{05c0cc1635fc46dca1e400ffaa6fa77d,
title = "Effects of Tocopherols and Tocotrienols on Body Composition and Bone Calcium Content in Adrenalectomized Rats Replaced with Dexamethasone",
abstract = "Long-term glucocorticoid treatment is associated with severe side effects, such as obesity and osteoporosis. A palm oil-derived vitamin E mixture had been shown previously to be protective against osteoporosis in rats given 120 μg/kg dexamethasone daily for 12 weeks. In this study we determined the effects of two isomers of vitamin E (i.e., palm oil-derived γ-tocotrienol and the commercially available α-tocopherol, 60 mg/kg of body weight/day) on body composition and bone calcium content in adrenalectomized rats replaced with two doses of dexamethasone, 120 μg/kg and 240 μg/kg daily. Treatment period was 8 weeks. γ-Tocotrienol (60 mg/kg of body weight/day) was found to reduce body fat mass and increase the fourth lumbar vertebra bone calcium content in these rats, while α-tocopherol (60 mg/kg of body weight/day) was ineffective. Therefore, in conclusion, palm oil-derived γ-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of the side effects of long-term glucocorticoid use.",
keywords = "α-tocopherol, γ-tocotrienol, Dexamethasone, Osteoporosis, Rats",
author = "Soelaiman, {Ima Nirwana} and S. Suhaniza",
year = "2004",
month = "3",
doi = "10.1089/109662004322984699",
language = "English",
volume = "7",
pages = "45--51",
journal = "Journal of Medicinal Food",
issn = "1096-620X",
publisher = "Mary Ann Liebert Inc.",
number = "1",

}

TY - JOUR

T1 - Effects of Tocopherols and Tocotrienols on Body Composition and Bone Calcium Content in Adrenalectomized Rats Replaced with Dexamethasone

AU - Soelaiman, Ima Nirwana

AU - Suhaniza, S.

PY - 2004/3

Y1 - 2004/3

N2 - Long-term glucocorticoid treatment is associated with severe side effects, such as obesity and osteoporosis. A palm oil-derived vitamin E mixture had been shown previously to be protective against osteoporosis in rats given 120 μg/kg dexamethasone daily for 12 weeks. In this study we determined the effects of two isomers of vitamin E (i.e., palm oil-derived γ-tocotrienol and the commercially available α-tocopherol, 60 mg/kg of body weight/day) on body composition and bone calcium content in adrenalectomized rats replaced with two doses of dexamethasone, 120 μg/kg and 240 μg/kg daily. Treatment period was 8 weeks. γ-Tocotrienol (60 mg/kg of body weight/day) was found to reduce body fat mass and increase the fourth lumbar vertebra bone calcium content in these rats, while α-tocopherol (60 mg/kg of body weight/day) was ineffective. Therefore, in conclusion, palm oil-derived γ-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of the side effects of long-term glucocorticoid use.

AB - Long-term glucocorticoid treatment is associated with severe side effects, such as obesity and osteoporosis. A palm oil-derived vitamin E mixture had been shown previously to be protective against osteoporosis in rats given 120 μg/kg dexamethasone daily for 12 weeks. In this study we determined the effects of two isomers of vitamin E (i.e., palm oil-derived γ-tocotrienol and the commercially available α-tocopherol, 60 mg/kg of body weight/day) on body composition and bone calcium content in adrenalectomized rats replaced with two doses of dexamethasone, 120 μg/kg and 240 μg/kg daily. Treatment period was 8 weeks. γ-Tocotrienol (60 mg/kg of body weight/day) was found to reduce body fat mass and increase the fourth lumbar vertebra bone calcium content in these rats, while α-tocopherol (60 mg/kg of body weight/day) was ineffective. Therefore, in conclusion, palm oil-derived γ-tocotrienol has the potential to be utilized as a prophylactic agent in prevention of the side effects of long-term glucocorticoid use.

KW - α-tocopherol

KW - γ-tocotrienol

KW - Dexamethasone

KW - Osteoporosis

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=1842476274&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842476274&partnerID=8YFLogxK

U2 - 10.1089/109662004322984699

DO - 10.1089/109662004322984699

M3 - Article

C2 - 15117552

AN - SCOPUS:1842476274

VL - 7

SP - 45

EP - 51

JO - Journal of Medicinal Food

JF - Journal of Medicinal Food

SN - 1096-620X

IS - 1

ER -