Effects of steroid hormones pretreatment on isoprenaline-induced cyclic adenosine 3′,5′-monophosphate in rat lung

Nabishah Mohamad, Z. Merican, P. B. Morat, A. K. Alias, B. A K Khalid

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

1. 1. Steroid hormones have been shown to regulate the concentration of adrenergic and muscarinic receptors in many tissues. 2. 2. The cyclic adenosine 3′,5′-monophosphate (cAMP) content in rat lung tissues in response to either dexamethasone, corticosterone, deoxycorticosterone or progesterone for 7 days were measured following intraperitoneal injection of isoprenaline just before sacrificed. 3. 3. There was a significant increase in cAMP level (P < 0.001) in dexamethasone and corticosteronetreated rats compared to controls that received isoprenaline alone. 4. 4. Pretreatment with deoxycorticosterone and progesterone suppressed the increase in cAMP in response to isoprenaline. 5. 5. The effect of glucocorticoids in causing bronchodilatation in asthmatic patients is partly due to the restoration of adenyl cyclase responsiveness to beta-agonist.

Original languageEnglish
Pages (from-to)935-938
Number of pages4
JournalGeneral Pharmacology
Volume21
Issue number6
DOIs
Publication statusPublished - 1990

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Isoproterenol
Adenosine
Desoxycorticosterone
Steroids
Hormones
Lung
Dexamethasone
Progesterone
Muscarinic Receptors
Corticosterone
Intraperitoneal Injections
Adenylyl Cyclases
Adrenergic Receptors
Glucocorticoids

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of steroid hormones pretreatment on isoprenaline-induced cyclic adenosine 3′,5′-monophosphate in rat lung. / Mohamad, Nabishah; Merican, Z.; Morat, P. B.; Alias, A. K.; Khalid, B. A K.

In: General Pharmacology, Vol. 21, No. 6, 1990, p. 935-938.

Research output: Contribution to journalArticle

Mohamad, Nabishah ; Merican, Z. ; Morat, P. B. ; Alias, A. K. ; Khalid, B. A K. / Effects of steroid hormones pretreatment on isoprenaline-induced cyclic adenosine 3′,5′-monophosphate in rat lung. In: General Pharmacology. 1990 ; Vol. 21, No. 6. pp. 935-938.
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