Effects of steroid hormones on cyclic adenosine 3',5'-monophosphate levels in the rat lung

Nabishah Mohamad, B. A K Khalid, P. B. Morat, A. K. Alias, M. Zainuddin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The possible role of cyclic adenosine 3',5'-monophosphate (cAMP) in mediating the action of steroid hormones was investigated using the rat lung. Male rats were adrenalectomized and treated with olive oil, dexamethasone, corticosterone, deoxycorticosterone (DOC) or progesterone. At the end of 10 days, 100 μg isoprenaline/kg was injected intraperitoneally 5 min before the animals were killed to stimulate cAMP production. Adrenalectomy significantly decreased cAMP levels in the rat lung. Dexamethasone and corticosterone pretreatment reversed the effect of adrenalectomy whereas progesterone pretreatment but not DOC pretreatment significantly decreased lung cAMP levels. Cyclic AMP levels in normal female rats, whether pregnant or not, were not significantly different from those in male rats. We concluded that the absence of glucocorticoid, as after adrenalectomy, decreased the cAMP levels in rat lungs and that this could be reversed by either dexamethasone or corticosterone replacement. Progesterone reduced the cAMP content in rat lungs by acting as a glucocorticoid antagonist or by acting directly via progesterone receptors.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalJournal of Endocrinology
Volume134
Issue number1
Publication statusPublished - 1992

Fingerprint

Cyclic AMP
Steroids
Hormones
Lung
Adrenalectomy
Corticosterone
Dexamethasone
Progesterone
Desoxycorticosterone
Glucocorticoids
Progesterone Receptors
Isoproterenol

ASJC Scopus subject areas

  • Endocrinology

Cite this

Mohamad, N., Khalid, B. A. K., Morat, P. B., Alias, A. K., & Zainuddin, M. (1992). Effects of steroid hormones on cyclic adenosine 3',5'-monophosphate levels in the rat lung. Journal of Endocrinology, 134(1), 73-76.

Effects of steroid hormones on cyclic adenosine 3',5'-monophosphate levels in the rat lung. / Mohamad, Nabishah; Khalid, B. A K; Morat, P. B.; Alias, A. K.; Zainuddin, M.

In: Journal of Endocrinology, Vol. 134, No. 1, 1992, p. 73-76.

Research output: Contribution to journalArticle

Mohamad, N, Khalid, BAK, Morat, PB, Alias, AK & Zainuddin, M 1992, 'Effects of steroid hormones on cyclic adenosine 3',5'-monophosphate levels in the rat lung', Journal of Endocrinology, vol. 134, no. 1, pp. 73-76.
Mohamad, Nabishah ; Khalid, B. A K ; Morat, P. B. ; Alias, A. K. ; Zainuddin, M. / Effects of steroid hormones on cyclic adenosine 3',5'-monophosphate levels in the rat lung. In: Journal of Endocrinology. 1992 ; Vol. 134, No. 1. pp. 73-76.
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