Effects of stereospecific positioning of fatty acids in triacylglycerol structures in native and randomized fats: A review of their nutritional implications

Tilakavati Karupaiah, Kalyana Sundram

Research output: Contribution to journalArticle

118 Citations (Scopus)

Abstract

Most studies on lipid lowering diets have focused on the total content of saturated, polyunsaturated and monounsaturated fatty acids. However, the distribution of these fatty acids on the triacylglycerol (TAG) molecule and the molecular TAG species generated by this stereospecificity are characteristic for various native dietary TAGs. Fat randomization or interesterification is a process involving the positional redistribution of fatty acids, which leads to the generation of new TAG molecular species. A comparison between native and randomized TAGs is the subject of this review with regards to the role of stereospecificity of fatty acids in metabolic processing and effects on fasting lipids and postprandial lipemia. The positioning of unsaturated versus saturated fatty acids in the sn-2 position of TAGs indicate differences in early metabolic processing and postprandial clearance, which may explain modulatory effects on atherogenecity and thrombogenecity. Both human and animal studies are discussed with implications for human health.

Original languageEnglish
Article number16
JournalNutrition and Metabolism
Volume4
DOIs
Publication statusPublished - 2007

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Triglycerides
Fatty Acids
Fats
Lipids
Monounsaturated Fatty Acids
Random Allocation
Hyperlipidemias
Unsaturated Fatty Acids
Fasting
Diet
Health

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Endocrinology, Diabetes and Metabolism

Cite this

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