Effects of plants and isolates of celastraceae family on cancer pathways

Bukhari Syed Nasir Abbas, Ibrahim Jantan, Mohamed Ali Seyed

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The evaluation of crude drugs of natural origin as sources of new effective anticancer agents continues to be important due to the lack of effective anticancer drugs currently used in practice which are generally accompanied with adverse effects at different levels of severity. The aim of this concise review is to gather existing literature on anticancer potential of extracts and compounds isolated from Celastraceae species. This review covers six genera (Maytenus, Tripterygium, Hippocratea, Gymnosporia, Celastrus and Austroplenckia) belonging to this family and their 33 isolates. Studies carried out by using different cell lines have shown remarkable indication of anticancer activity, however, only a restricted number of studies have been reported using in vivo tumor models. Some of the compounds, such as triptolide, celastrol and demethylzeylasteral from T. wilfordii, have been extensively studied on their mechanisms of action due to their potent activity on various cancer cell lines. Such promising lead compounds should generate considerable interest among scientists to improve their therapeutic potential with fewer side effects by molecular modification.

Original languageEnglish
Pages (from-to)681-693
Number of pages13
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume15
Issue number6
Publication statusPublished - 1 Jul 2015

Fingerprint

Celastraceae
Hippocrateaceae
Celastrus
Maytenus
Tripterygium
Cell Line
Drug Evaluation
Antineoplastic Agents
Neoplasms
Pharmaceutical Preparations
Therapeutics

Keywords

  • Anticancer activity
  • Celastraceae
  • Cytotoxic
  • Tripterygium species
  • Triptolide

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

Cite this

Syed Nasir Abbas, B., Jantan, I., & Seyed, M. A. (2015). Effects of plants and isolates of celastraceae family on cancer pathways. Anti-Cancer Agents in Medicinal Chemistry, 15(6), 681-693.

Effects of plants and isolates of celastraceae family on cancer pathways. / Syed Nasir Abbas, Bukhari; Jantan, Ibrahim; Seyed, Mohamed Ali.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 15, No. 6, 01.07.2015, p. 681-693.

Research output: Contribution to journalArticle

Syed Nasir Abbas, B, Jantan, I & Seyed, MA 2015, 'Effects of plants and isolates of celastraceae family on cancer pathways', Anti-Cancer Agents in Medicinal Chemistry, vol. 15, no. 6, pp. 681-693.
Syed Nasir Abbas, Bukhari ; Jantan, Ibrahim ; Seyed, Mohamed Ali. / Effects of plants and isolates of celastraceae family on cancer pathways. In: Anti-Cancer Agents in Medicinal Chemistry. 2015 ; Vol. 15, No. 6. pp. 681-693.
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