Effects of Piper sarmentosum (kaduk) water extract on adiponectin and blood glucose levels in ovariectomy-induced obese rats

A. Aida Azlina, Farihah Suhaimi, Qodriyah Mohd Saad, Nur Azlina Mohd Fahami

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The study was conducted to evaluate the effects of Piper sarmentosum (PS) extract and glycyrrhizic acid (GCA) on plasma adiponectin and blood glucose in ovariectomy-induced obese rats. Twenty eight female Sprague-Dawley rats were randomly divided into four groups. Three groups were ovariectomized (OVX), while the remaining group underwent sham operation. The OVX groups were given PS water extract (0.125 g kg-1), GCA (0.120 g kg-1) and water (CTRL), respectively, while the Sham-Operated (SHM) group received only water. Plasma adiponectin and blood glucose were measured at zero, three and five months of treatment, while body weight was measured weekly. All the OVX groups had a significant reduction (p<0.05) in the plasma adiponectin compared to the SHM group. After three and five months of treatment, both PS and GCA treated group showed a significant increment (p<0.05) in the plasma adiponectin level compared to CTRL group. While, the blood glucose level, only PS treated group showed significant reduction (p<0.05) after three and five months of treatment compared to CTRL group but no significant difference (p<0.05) occurred in body weight compared to CTRL group. Our finding suggests that water extract of Piper sarmentosum may have the ability to reduce the amount of visceral fat in the body as shown by the increment of plasma adiponectin and improve blood glucose levels in obese rats.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalResearch Journal of Medicinal Plant
Volume3
Issue number3
DOIs
Publication statusPublished - 2009

Fingerprint

Piper
Adiponectin
Ovariectomy
Blood Glucose
Glycyrrhizic Acid
Water
Body Weight
Intra-Abdominal Fat
Sprague Dawley Rats

Keywords

  • Adiponectin
  • Blood glucose
  • Obesity
  • Ovariectomy
  • Piper sarmentosum

ASJC Scopus subject areas

  • Complementary and alternative medicine

Cite this

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title = "Effects of Piper sarmentosum (kaduk) water extract on adiponectin and blood glucose levels in ovariectomy-induced obese rats",
abstract = "The study was conducted to evaluate the effects of Piper sarmentosum (PS) extract and glycyrrhizic acid (GCA) on plasma adiponectin and blood glucose in ovariectomy-induced obese rats. Twenty eight female Sprague-Dawley rats were randomly divided into four groups. Three groups were ovariectomized (OVX), while the remaining group underwent sham operation. The OVX groups were given PS water extract (0.125 g kg-1), GCA (0.120 g kg-1) and water (CTRL), respectively, while the Sham-Operated (SHM) group received only water. Plasma adiponectin and blood glucose were measured at zero, three and five months of treatment, while body weight was measured weekly. All the OVX groups had a significant reduction (p<0.05) in the plasma adiponectin compared to the SHM group. After three and five months of treatment, both PS and GCA treated group showed a significant increment (p<0.05) in the plasma adiponectin level compared to CTRL group. While, the blood glucose level, only PS treated group showed significant reduction (p<0.05) after three and five months of treatment compared to CTRL group but no significant difference (p<0.05) occurred in body weight compared to CTRL group. Our finding suggests that water extract of Piper sarmentosum may have the ability to reduce the amount of visceral fat in the body as shown by the increment of plasma adiponectin and improve blood glucose levels in obese rats.",
keywords = "Adiponectin, Blood glucose, Obesity, Ovariectomy, Piper sarmentosum",
author = "Azlina, {A. Aida} and Farihah Suhaimi and {Mohd Saad}, Qodriyah and {Mohd Fahami}, {Nur Azlina}",
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AU - Azlina, A. Aida

AU - Suhaimi, Farihah

AU - Mohd Saad, Qodriyah

AU - Mohd Fahami, Nur Azlina

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