Effects of palmvitee (palm oil derived tocotrienol rich fraction vitamin E) on lipid profile and antioxidant status in rats fed on high cholesterol diet

H. M. Nawawi, S. Mamat, M. Muhajir, M. A. Abu Bakar, Jamaludin Mohamed

Research output: Contribution to journalArticle

Abstract

Palmvitee (pv) has anti-oxidant properties but its effects on lipid profile and antioxidant status with different cholesterol diet remains unclear. The objectives of this study were to investigate the effects of pv on serum lipid profile and antioxidant status - serum malondialdehyde [MDA] concentration and antioxidant activity [AOA] in rats fed on high (HC) or normal cholesterol (NC) diets. Forty rats were recruited and divided into four diet groups: NC diet without pv [K1], NC diet with pv [K2], HC diet without pv [K3] and HC diet with pv [K4]. Serum fasting lipid profile, MDA and total AOA were measured at baseline, two and three months. There was significantly greater TG increment in K4 than K3 (p < 0.05). There was significantly greater MDA reduction in (a) K2 than K1 (p < 0.05) and in (b) K4 than K3 (p < 0.01). The K3 compared to K1 group showed significantly greater reduction in TG (p < 0.05) and MDA (p < 0.05). The K4 compared to K2 group showed significantly lower increment in TG (p < 0.05) and MDA (p < 0.01). The K4 group showed the greatest MDA reduction, compared to K3 (p < 0.01), K2 (p < 0.01) or K1 (p < 0.005). At three months, K3 had significantly higher increment in total AOA than K1. In conclusion, pv increases TG levels but inhibits MDA increment irrespective of the level of cholesterol in the diet. The high compared to normal cholesterol diet leads to greater reduction in TG and MDA levels. Combination of high cholesterol diet and pv exhibits an accentuated MDA inhibiting effect, probably indirectly via TG lowering effect of the former, but more so by the anti-oxidant property of pv.

Original languageEnglish
Pages (from-to)91-98
Number of pages8
JournalAsia Pacific Journal of Pharmacology
Volume15
Issue number4
Publication statusPublished - 2001

Fingerprint

Tocotrienols
Vitamin E
Malondialdehyde
Antioxidants
Cholesterol
Diet
Lipids
Oxidants
Serum
palm oil
Fasting

Keywords

  • Antioxidant
  • Cholesterol diet
  • Lipid profile
  • Malondialdehyde
  • Palmvitee
  • Tocotrienol-rich fraction vitamin E

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of palmvitee (palm oil derived tocotrienol rich fraction vitamin E) on lipid profile and antioxidant status in rats fed on high cholesterol diet. / Nawawi, H. M.; Mamat, S.; Muhajir, M.; Abu Bakar, M. A.; Mohamed, Jamaludin.

In: Asia Pacific Journal of Pharmacology, Vol. 15, No. 4, 2001, p. 91-98.

Research output: Contribution to journalArticle

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