Effects of nicardipine on lipid peroxidation in rabbits given 2% cholesterol diet

N. M. Ismail, Kamsiah Jaarin, S. K. Vasudevan, S. Hashim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Nicardipine has been shown to have an anti-atherogenic effect in rabbits given a 2% cholesterol diet. Current evidence suggests that lipid peroxidation plays an important role in atherogenesis. This study examines the effect of nicardipine on lipid peroxidation in rabbits given a 2% cholesterol diet, 8 of these rabbits given nicardipine 0.5 mg kg twice daily intramuscularly for ten weeks while the remaining untreated 6 were controls. After ten weeks, serum malondialdehyde in the control group was significantly higher compared to their baseline levels (P<0.05). However, there was no increase in serum malondialdehyde in the nicardipine group after 10 weeks. The area of Sudan IV positive intimal lesions (atherosclerotic plaques) were significantly decreased (P<0.01) in the treated group compared to the control group. The aortic tissue content of cholesterol and diene conjugates were also decreased in the nicardipine group (P<0.01). These findings suggest a possible link between nicardipine and lipid peroxidation in mediating its antiatherogenic effects.

Original languageEnglish
Pages (from-to)10-15
Number of pages6
JournalPharmacology and Toxicology
Volume77
Issue number1
Publication statusPublished - 1995

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Nicardipine
Nutrition
Lipid Peroxidation
Cholesterol
Diet
Rabbits
Lipids
Malondialdehyde
Tunica Intima
Control Groups
Atherosclerotic Plaques
Serum
Atherosclerosis
Tissue

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Pharmacology
  • Toxicology

Cite this

Effects of nicardipine on lipid peroxidation in rabbits given 2% cholesterol diet. / Ismail, N. M.; Jaarin, Kamsiah; Vasudevan, S. K.; Hashim, S.

In: Pharmacology and Toxicology, Vol. 77, No. 1, 1995, p. 10-15.

Research output: Contribution to journalArticle

Ismail, N. M. ; Jaarin, Kamsiah ; Vasudevan, S. K. ; Hashim, S. / Effects of nicardipine on lipid peroxidation in rabbits given 2% cholesterol diet. In: Pharmacology and Toxicology. 1995 ; Vol. 77, No. 1. pp. 10-15.
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