Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children

W. M. Wan Nazaimoon, A. Osman, Loo Ling Wu, B. A K Khalid

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective. The expression and synthesis of IGF-I and IGFBP3 have been shown to be regulated by hormones and nutrition. We study the effects of malnutrition and iodine deficiency on these growth factors and the height attainment of a group of children. Design. We measured serum IGF-I and IGFBP-3 levels in a group of Malaysian aborigine children from three jungle settlements; Sinderut and Pos Lanai are known for iodine deficiency and endemic goitre, and Gombak is an iodine replete area with better socioeconomic status. Patients. A total of 246 children were studied, 188 in the age group 4-10 years and 88 in the age group 11-15 years. Measurements. All children were assessed anthropometrically and height standard deviation score (SDS) were calculated using the CDC Anthropometric Software package. Malnutrition was confirmed clinically and according to the WHO definition of malnutrition. IGF-I and IGFBP-8 were determined by radioimmunoassay, and T4 and TSH by immunoradiometric assay. Results. Based on the height SDS, Sinderut and Pos Lanai children were significantly more malnourished and stunted than the Gombak children P = 0.0001). T4 levels were significantly lower (P = 0.0001) amongst the 4-10-years old Sinderut (81 ± 2 nmol/l) than in Pos Lanai (101 ± 3 nmol/l) or Gombak (123 ± 3 nmol/l) children. Similar findings were also seen in the older children; mean T4 levels of those from Sinderut and Pos Lanai (83 ± 3 and 88 ± 4 nmol/l respectively), were low (P = 0.0001) compared to' Gombak (118 ± 3 nmol/l). Conversely, TSH levels in both age groups of Sinderut children were significantly elevated (P = 0.0001) (35 ± 0.2 and 3.9 ± 0.3 mU/l respectively) compared to age-matched groups from Pos Lanai (2.1 ± 0.1 and 2.2 ± 0.2 mU/l respectively) and Gombak (1.5 ± 0.1 and 1.5 ± 0.2 mU/l respectively). IGF-I and IGFBP-3 correlated significantly with the height SDS of the children, in both the 4-10 (r = 0.400, P = 0.0001 and r = 0.365, P = 0.0001 respectively) and 11-15 years age group; (r = 0.324, P = 0.002 and r = 0.533, P = 0.0001 respectively). Correlation between IGFBP-3 and T4 levels was more significant in the younger children (r = 0.412, P = 0.001). Association between IGF-I and T4 levels was significant only in the 4-10 years age group (r = 0.237, P = 0.001). Conclusions. Varying duration and degree of exposure to malnutrition and iodine deficiency resulted in different mean levels of T4, TSH, IGF-I and IGFBP-3 in the three areas. The strong positive associations be!tween IGF-I and IGFBP-3 levels and height SDS suggest that these biochemical measurements are indeed useful indicators of growth and nutritional status in children. The significant correlations between T4 and IGFBP-3 and IGF-I suggests the importance of thyroid hormones in regulating the synthesis of these growth factors. The age-related increase of these growth factors even amongst mainourished, iodine deficient children implies that age-matched reference ranges are essential for proper evaluation of laboratory results.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalClinical Endocrinology
Volume45
Issue number1
DOIs
Publication statusPublished - 1996

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Insulin-Like Growth Factor Binding Protein 3
Iodine
Insulin-Like Growth Factor I
Age Groups
Malnutrition
Intercellular Signaling Peptides and Proteins
Insulin-Like Growth Factor I Deficiency
Endemic Goiter
Connective Tissue Growth Factor
Immunoradiometric Assay
Polysorbates
Centers for Disease Control and Prevention (U.S.)
Nutritional Status
Thyroid Hormones
Social Class
Radioimmunoassay
Reference Values

ASJC Scopus subject areas

  • Endocrinology

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Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children. / Wan Nazaimoon, W. M.; Osman, A.; Wu, Loo Ling; Khalid, B. A K.

In: Clinical Endocrinology, Vol. 45, No. 1, 1996, p. 79-83.

Research output: Contribution to journalArticle

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title = "Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children",
abstract = "Objective. The expression and synthesis of IGF-I and IGFBP3 have been shown to be regulated by hormones and nutrition. We study the effects of malnutrition and iodine deficiency on these growth factors and the height attainment of a group of children. Design. We measured serum IGF-I and IGFBP-3 levels in a group of Malaysian aborigine children from three jungle settlements; Sinderut and Pos Lanai are known for iodine deficiency and endemic goitre, and Gombak is an iodine replete area with better socioeconomic status. Patients. A total of 246 children were studied, 188 in the age group 4-10 years and 88 in the age group 11-15 years. Measurements. All children were assessed anthropometrically and height standard deviation score (SDS) were calculated using the CDC Anthropometric Software package. Malnutrition was confirmed clinically and according to the WHO definition of malnutrition. IGF-I and IGFBP-8 were determined by radioimmunoassay, and T4 and TSH by immunoradiometric assay. Results. Based on the height SDS, Sinderut and Pos Lanai children were significantly more malnourished and stunted than the Gombak children P = 0.0001). T4 levels were significantly lower (P = 0.0001) amongst the 4-10-years old Sinderut (81 ± 2 nmol/l) than in Pos Lanai (101 ± 3 nmol/l) or Gombak (123 ± 3 nmol/l) children. Similar findings were also seen in the older children; mean T4 levels of those from Sinderut and Pos Lanai (83 ± 3 and 88 ± 4 nmol/l respectively), were low (P = 0.0001) compared to' Gombak (118 ± 3 nmol/l). Conversely, TSH levels in both age groups of Sinderut children were significantly elevated (P = 0.0001) (35 ± 0.2 and 3.9 ± 0.3 mU/l respectively) compared to age-matched groups from Pos Lanai (2.1 ± 0.1 and 2.2 ± 0.2 mU/l respectively) and Gombak (1.5 ± 0.1 and 1.5 ± 0.2 mU/l respectively). IGF-I and IGFBP-3 correlated significantly with the height SDS of the children, in both the 4-10 (r = 0.400, P = 0.0001 and r = 0.365, P = 0.0001 respectively) and 11-15 years age group; (r = 0.324, P = 0.002 and r = 0.533, P = 0.0001 respectively). Correlation between IGFBP-3 and T4 levels was more significant in the younger children (r = 0.412, P = 0.001). Association between IGF-I and T4 levels was significant only in the 4-10 years age group (r = 0.237, P = 0.001). Conclusions. Varying duration and degree of exposure to malnutrition and iodine deficiency resulted in different mean levels of T4, TSH, IGF-I and IGFBP-3 in the three areas. The strong positive associations be!tween IGF-I and IGFBP-3 levels and height SDS suggest that these biochemical measurements are indeed useful indicators of growth and nutritional status in children. The significant correlations between T4 and IGFBP-3 and IGF-I suggests the importance of thyroid hormones in regulating the synthesis of these growth factors. The age-related increase of these growth factors even amongst mainourished, iodine deficient children implies that age-matched reference ranges are essential for proper evaluation of laboratory results.",
author = "{Wan Nazaimoon}, {W. M.} and A. Osman and Wu, {Loo Ling} and Khalid, {B. A K}",
year = "1996",
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volume = "45",
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TY - JOUR

T1 - Effects of iodine deficiency on insulin-like growth factor-I, insulin-like growth factor-binding protein-3 levels and height attainment in malnourished children

AU - Wan Nazaimoon, W. M.

AU - Osman, A.

AU - Wu, Loo Ling

AU - Khalid, B. A K

PY - 1996

Y1 - 1996

N2 - Objective. The expression and synthesis of IGF-I and IGFBP3 have been shown to be regulated by hormones and nutrition. We study the effects of malnutrition and iodine deficiency on these growth factors and the height attainment of a group of children. Design. We measured serum IGF-I and IGFBP-3 levels in a group of Malaysian aborigine children from three jungle settlements; Sinderut and Pos Lanai are known for iodine deficiency and endemic goitre, and Gombak is an iodine replete area with better socioeconomic status. Patients. A total of 246 children were studied, 188 in the age group 4-10 years and 88 in the age group 11-15 years. Measurements. All children were assessed anthropometrically and height standard deviation score (SDS) were calculated using the CDC Anthropometric Software package. Malnutrition was confirmed clinically and according to the WHO definition of malnutrition. IGF-I and IGFBP-8 were determined by radioimmunoassay, and T4 and TSH by immunoradiometric assay. Results. Based on the height SDS, Sinderut and Pos Lanai children were significantly more malnourished and stunted than the Gombak children P = 0.0001). T4 levels were significantly lower (P = 0.0001) amongst the 4-10-years old Sinderut (81 ± 2 nmol/l) than in Pos Lanai (101 ± 3 nmol/l) or Gombak (123 ± 3 nmol/l) children. Similar findings were also seen in the older children; mean T4 levels of those from Sinderut and Pos Lanai (83 ± 3 and 88 ± 4 nmol/l respectively), were low (P = 0.0001) compared to' Gombak (118 ± 3 nmol/l). Conversely, TSH levels in both age groups of Sinderut children were significantly elevated (P = 0.0001) (35 ± 0.2 and 3.9 ± 0.3 mU/l respectively) compared to age-matched groups from Pos Lanai (2.1 ± 0.1 and 2.2 ± 0.2 mU/l respectively) and Gombak (1.5 ± 0.1 and 1.5 ± 0.2 mU/l respectively). IGF-I and IGFBP-3 correlated significantly with the height SDS of the children, in both the 4-10 (r = 0.400, P = 0.0001 and r = 0.365, P = 0.0001 respectively) and 11-15 years age group; (r = 0.324, P = 0.002 and r = 0.533, P = 0.0001 respectively). Correlation between IGFBP-3 and T4 levels was more significant in the younger children (r = 0.412, P = 0.001). Association between IGF-I and T4 levels was significant only in the 4-10 years age group (r = 0.237, P = 0.001). Conclusions. Varying duration and degree of exposure to malnutrition and iodine deficiency resulted in different mean levels of T4, TSH, IGF-I and IGFBP-3 in the three areas. The strong positive associations be!tween IGF-I and IGFBP-3 levels and height SDS suggest that these biochemical measurements are indeed useful indicators of growth and nutritional status in children. The significant correlations between T4 and IGFBP-3 and IGF-I suggests the importance of thyroid hormones in regulating the synthesis of these growth factors. The age-related increase of these growth factors even amongst mainourished, iodine deficient children implies that age-matched reference ranges are essential for proper evaluation of laboratory results.

AB - Objective. The expression and synthesis of IGF-I and IGFBP3 have been shown to be regulated by hormones and nutrition. We study the effects of malnutrition and iodine deficiency on these growth factors and the height attainment of a group of children. Design. We measured serum IGF-I and IGFBP-3 levels in a group of Malaysian aborigine children from three jungle settlements; Sinderut and Pos Lanai are known for iodine deficiency and endemic goitre, and Gombak is an iodine replete area with better socioeconomic status. Patients. A total of 246 children were studied, 188 in the age group 4-10 years and 88 in the age group 11-15 years. Measurements. All children were assessed anthropometrically and height standard deviation score (SDS) were calculated using the CDC Anthropometric Software package. Malnutrition was confirmed clinically and according to the WHO definition of malnutrition. IGF-I and IGFBP-8 were determined by radioimmunoassay, and T4 and TSH by immunoradiometric assay. Results. Based on the height SDS, Sinderut and Pos Lanai children were significantly more malnourished and stunted than the Gombak children P = 0.0001). T4 levels were significantly lower (P = 0.0001) amongst the 4-10-years old Sinderut (81 ± 2 nmol/l) than in Pos Lanai (101 ± 3 nmol/l) or Gombak (123 ± 3 nmol/l) children. Similar findings were also seen in the older children; mean T4 levels of those from Sinderut and Pos Lanai (83 ± 3 and 88 ± 4 nmol/l respectively), were low (P = 0.0001) compared to' Gombak (118 ± 3 nmol/l). Conversely, TSH levels in both age groups of Sinderut children were significantly elevated (P = 0.0001) (35 ± 0.2 and 3.9 ± 0.3 mU/l respectively) compared to age-matched groups from Pos Lanai (2.1 ± 0.1 and 2.2 ± 0.2 mU/l respectively) and Gombak (1.5 ± 0.1 and 1.5 ± 0.2 mU/l respectively). IGF-I and IGFBP-3 correlated significantly with the height SDS of the children, in both the 4-10 (r = 0.400, P = 0.0001 and r = 0.365, P = 0.0001 respectively) and 11-15 years age group; (r = 0.324, P = 0.002 and r = 0.533, P = 0.0001 respectively). Correlation between IGFBP-3 and T4 levels was more significant in the younger children (r = 0.412, P = 0.001). Association between IGF-I and T4 levels was significant only in the 4-10 years age group (r = 0.237, P = 0.001). Conclusions. Varying duration and degree of exposure to malnutrition and iodine deficiency resulted in different mean levels of T4, TSH, IGF-I and IGFBP-3 in the three areas. The strong positive associations be!tween IGF-I and IGFBP-3 levels and height SDS suggest that these biochemical measurements are indeed useful indicators of growth and nutritional status in children. The significant correlations between T4 and IGFBP-3 and IGF-I suggests the importance of thyroid hormones in regulating the synthesis of these growth factors. The age-related increase of these growth factors even amongst mainourished, iodine deficient children implies that age-matched reference ranges are essential for proper evaluation of laboratory results.

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